Maternal hyperuricemia in normotensive singleton pregnancy, a prenatal finding with continuous perinatal and postnatal effects, a prospective cohort study

BMC Pregnancy and Childbirth

Maryam Kashanian³  Alireza Abdollahi⁴  Mamak Shariat¹  Sedigheh Hantoushzadeh¹  Mahdi Sheikh²  Elaheh Amini² 

[1] Maternal, Fetal and Neonatal Research Center, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran;Breastfeeding Research Center, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Obstetrics & Gynecology, Akbarabadi Teaching Hospital, Tehran University of Medical Sciences, Tehran, Iran;Department of Pathology, Imam Khomeini Hospital complexes, Tehran University of Medical Sciences, Tehran, Iran

关键词: IVH;    Pregnancy;    Neonatal;    Uric acid;    Hyperuricemia;   

Others  :  1127504
DOI  :  10.1186/1471-2393-14-104

 received in 2014-01-06, accepted in 2014-03-12,  发布年份 2014

【 摘 要 】

Background

To assess the association of maternal hyperuricemia with adverse pregnancy outcome and neonatal metabolic, neurologic and respiratory disturbances in normotensive singleton pregnant women.

Method

This prospective multicentric cohort study was conducted on 404 normotensive singleton pregnant women who were admitted for delivery in Vali-Asr and Akbar-Abadi teaching hospitals of Tehran University of Medical Sciences, Tehran, Iran. Upon enrollment maternal and umbilical sera were obtained for determining uric acid levels. 1 and 5 minutes Apgar scores, the need for neonatal resuscitation and neonatal intensive care unit (NICU) admission were recorded. In case of NICU admission a neonatal blood sample was drawn for determining uric acid, blood sugar and bilirubin levels. An intracranial ultrasound imaging was also carried out for the admittd neonates for detecting intraventricular hemorrhage.

Results

Maternal hyperuricemia (uric acid one standard deviation greater than the appropriate gestational age) was independently associated with preterm birth (odds ratio (OR), 3.17; 95% confidence interval (CI), 2.1 – 4.79), small for gestational age delivery (OR, 1.28; 95% CI, 1.04 – 2.57), NICU admission (OR, 1.65; 95% CI, 1.12 – 2.94) and neonatal IVH (OR, 8.14; 95% CI, 1.11 – 87.1).

Conclusions

Maternal hyperuricemia in normotensive singleton pregnant women is significantly associated with preterm and SGA delivery and the development of neonatal IVH.

【 授权许可】

   
2014 Amini et al.; licensee BioMed Central Ltd.

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