期刊论文详细信息
BMC Endocrine Disorders
Combining glycosylated hemoglobin A1c and fasting plasma glucose for diagnosis of type 2 diabetes in Chinese adults
Wang-Hong Xu2  Rui Li3  Qingwu Jiang2  Yanyun Li3  Qundi Yang3  Dajiang Lu1  Liang Shi3  Hua Zhang2  Ye Ruan3  Genming Zhao2  Weijian Zhong3  Miao Mo2 
[1] School of Sports Science, Shanghai University of Sport, 399 Chang Hai Road, Shanghai 200438, People’s Republic of China;Department of Epidemiology, School of Public Health; Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, People’s Republic of China;Shanghai Municipal Center for Disease Control and Prevention, 1380 Zhong Shan Xi Road, Shanghai 200336, People’s Republic of China
关键词: Chinese adults;    Fasting plasma glucose;    Glycosylated hemoglobin A1c;    Diagnosis;    Type 2 diabetes;   
Others  :  1085597
DOI  :  10.1186/1472-6823-13-44
 received in 2013-03-28, accepted in 2013-09-30,  发布年份 2013
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【 摘 要 】

Background

Glycosylated hemoglobin A1c (HbA1c) has been applied to identify type 2 diabetes (T2DM) in the U.S. and European countries. It has not been used in China mainly due to lack of a standardized approach to measure HbA1c, short of knowledge about racial-specific standard and deficiency of an optimal cut-off point.

Methods

To evaluate combination of HbA1c and fasting plasma glucose (FPG) in diagnosing T2DM in Chinese adults, a multistage sampling cross-sectional study was conducted in Shanghai, China, in 2009. The FPG measurement, HbA1c assay, and oral glucose tolerance test (OGTT) were performed in 6,661 Chinese adults (3057 men, 3604 women) who had no prior history of diabetes to identify the unrecognized T2DM.

Results

A total of 454 participants were identified as T2DM based on the 1999 World Health Organization (WHO) diagnostic criteria. Of these patients, 239 were detected using an FPG ≥ 7.0 mmol/l and 141 were further identified using an HbA1c ≥ 43 mmol/mol (6.1%), achieving a sensitivity of 83.7% and a specificity of 89.3% for combining use of FPG and HbA1c. In subjects at high risk of diabetes, the combining use of FPG and HbA1c produced a higher sensitivity and an improved positive predictive value (PPV), and had a satisfactory specificity and negative predictive value (NPV).

Conclusions

The combining use of FPG and HbA1c is a potential screening and diagnosis approach for T2DM in Chinese adults, especially among those at high risk of the disease.

【 授权许可】

   
2013 Mo et al.; licensee BioMed Central Ltd.

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