Etiologic profile and antimicrobial susceptibility of community-acquired urinary tract infection in two Cameroonian towns

BMC Research Notes

Esemu Nkie Seraphine¹  Njom Henry Akum¹  Suylika Yvonne²  Jane-Francis Tatah Kihla Akoachere¹ 

[1] Laboratory for Emerging Infectious Diseases, Faculty of Science, University of Buea, Buea, Cameroon;Department of Microbiology and Parasitology, Faculty of Science, University of Buea, Buea, Cameroon

关键词: Cameroon;    Antibiotic susceptibility;    Bacteria;    Community-acquired urinary tract infection;   

Others  :  1166455
DOI  :  10.1186/1756-0500-5-219

 received in 2012-01-31, accepted in 2012-04-19,  发布年份 2012

【 摘 要 】

Background

Urinary tract infection (UTI) represents one of the most common diseases encountered in community medical practice. In resource poor settings, treatment is usually empiric due to the high cost and long duration required for reporting diagnosis by culture and antibiotic susceptibility testing. With the growing problem of drug resistance knowledge of antibiotic susceptibility pattern is pertinent for successful eradication of invading pathogens. Our study, the first of its kind in Cameroon, analyzed the distribution and antibiotic susceptibility of bacteria causing community-acquired urinary tract infection (CAUTI) in two towns (Bamenda and Buea) with a large number of young and middle aged persons, to provide data that could guide empiric treatment.

Findings

We cultured 235 urine specimens and analyzed the antibiotic susceptibility of isolates by the disc diffusion technique. Uropathogens were recovered from 137 (58.3%), with prevalence rates in Buea and Bamenda being 65.9% and 54% respectively. Predominant pathogens were Escherichia coli (31.4%), Klebsiella oxytoca (25.5%) and Staphylococcus spp (24.1%). Geographic variation in uropathogen distribution and antibiotic susceptibility was observed, and a significant difference in pathogen distribution with respect to gender. The 20–39 years age group had the highest prevalence of infection. All pathogens isolated were detected in this group. Isolates exhibited low susceptibility to antibiotics tested. Bamenda isolates generally exhibited lower susceptibility compared to those from Buea.

Conclusion

Regional variation in etiology of CAUTI and antibiotic susceptibility observed in our study emphasizes the need to establish local and national antimicrobial resistance monitoring systems in Cameroon to provide information for the development of CAUTI treatment guidelines.

【 授权许可】

   
2012 Akoachere et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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