Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

BMC Geriatrics

Dong-Hyun Kim⁶  Kyung-Soon Hong³  Jin-Young Jeong¹  Ohk-Hyun Ryu⁴  Shanai Quan⁶  Sohee Oh⁵  Hong Ji Song² 

[1] Korea Health Promotion Foundation, Seoul, Korea;Department of Family Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Halym University, Anyang, Korea;Department of Cardiology, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea;Department of Endocrinology, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea;Department of Biostatistics, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea;Hallym Research Institute of Clinical Epidemiology, Chuncheon, Korea

关键词: Ageing;    Gender difference;    Body composition;    Older adults;    Adiponectin;   

Others  :  855487
DOI  :  10.1186/1471-2318-14-8

 received in 2013-07-23, accepted in 2014-01-15,  发布年份 2014

【 摘 要 】

Background

Body composition changes with ageing can influence the adiponectin concentration. However, the component of body composition that is associated with adiponectin concentrations in older adults remains unclear.

Methods

There were 152 males and 168 females aged 65 years or older that participated in the 2010 Hallym Aging Study (HAS). Body composition (assessed by dual energy X-ray absorptiometry; DXA), anthropometric parameters and adiponectin were obtained from all participants. Multivariate linear regression models assessed the association of body fat percentage, regional muscle and bone mineral contents of body composition and waist/height ratio with adiponectin concentration. Age, albumin, testosterone concentration and metabolic parameters were considered as confounding factors.

Results

In correlation analysis, age was positively associated with adiponectin in males (P < 0.01), but not in females. Fasting glucose, albumin, arm skeletal muscle mass and bone mineral content were negatively associated with adiponectin in males (P < 0.05). Testosterone and leg bone mineral content were negatively associated with adiponectin in females (P < 0.05). In multivariate linear regression models, body fat percentage and albumin (P < 0.05) were negatively associated with adiponectin, and high-density lipoprotein cholesterol (HDL-C) (P < 0.001) and age (P < 0.01) were positively associated with adiponectin in older males. In older females, the only factors that correlated significantly with adiponectin concentration were the homeostasis model assessment of insulin resistance (P < 0.001) and HDL-C (P < 0.05). The waist/height ratio and bone mineral content were not associated with adiponectin in either gender.

Conclusion

Plasma adiponectin levels correlated negatively with body fat percentage in older males but not in older females. The differential results between older males and females suggest that certain gender-specific mechanisms may affect the association between adiponectin and age-related body composition changes.

【 授权许可】

   
2014 Song et al.; licensee BioMed Central Ltd.

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