Growth effects of exclusive breastfeeding promotion by peer counsellors in sub-Saharan Africa: the cluster-randomised PROMISE EBF trial

BMC Public Health

Thorkild Tylleskär^1,10  Halvor Sommerfelt⁹  Chipepo Kankasa⁴  Philippe Van de Perre^1,11  Eva-Charlotte Ekström⁵  James K Tumwine⁸  Nicolas Meda⁷  Henry Wamani³  David Sanders²  Vundli Ramokolo⁶  Jolly Nankunda⁸  Sonja Swanvelder¹  Carl Lombard¹  Tanya Doherty⁶  Abdoulaye Hama Diallo⁷  Victoria Nankabirwa³  Lars Thore Fadnes^1,12  Debra Jackson²  Ingunn Marie Stadskleiv Engebretsen^1,10 

[1]Biostatistics Unit, Medical Research Council, 7505 Cape Town, South Africa

[2]School of Public Health, University of Western Cape, P Bag X17, Bellville 7535, South Africa

[3]School of Public Health, Makerere University, Kampala, Uganda

[4]Department of Paediatrics and Child Health, School of Medicine, University of Zambia, Lusaka, Zambia

[5]Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

[6]Health Systems Research Unit, Medical Research Council, 7505 Cape Town, South Africa

[7]Centre MURAZ, Ministry of Health, PO Box 390, Bobo-Dioulasso, Burkina Faso

[8]Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda

[9]Department of International Public Health, Norwegian Institute of Public Health, N-0403 Oslo, Norway

[10]Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, PO Box 7804, 5020 Bergen, Norway

[11]Centre Hospitalier Universitaire Montpellier, Département de Bactériologie-Virologie, Montpellier, France

[12]Department of Clinical Dentistry, University of Bergen, PO Box 7804, 5020 Bergen, Norway

关键词: Community randomised trial;    Undernutrition;    Underweight;    Wasting;    Stunting;    Anthropometry;    Child growth;    Peer counselling;    Exclusive breastfeeding promotion;   

Others  :  1129156
DOI  :  10.1186/1471-2458-14-633

 received in 2013-04-17, accepted in 2014-06-15,  发布年份 2014

【 摘 要 】

Background

In this multi-country cluster-randomized behavioural intervention trial promoting exclusive breastfeeding (EBF) in Africa, we compared growth of infants up to 6 months of age living in communities where peer counsellors promoted EBF with growth in those infants living in control communities.

Methods

A total of 82 clusters in Burkina Faso, Uganda and South Africa were randomised to either the intervention or the control arm. Feeding data and anthropometric measurements were collected at visits scheduled 3, 6, 12 and 24 weeks post-partum. We calculated weight-for-length (WLZ), length-for-age (LAZ) and weight-for-age (WAZ) z-scores. Country specific adjusted Least Squares Means with 95% confidence intervals (CI) based on a longitudinal analysis are reported. Prevalence ratios (PR) for the association between peer counselling for EBF and wasting (WLZ < −2), stunting (LAZ < −2) and underweight (WAZ < −2) were calculated at each data collection point.

Results

The study included a total of 2,579 children. Adjusting for socio-economic status, the mean WLZ at 24 weeks were in Burkina Faso −0.20 (95% CI −0.39 to −0.01) and in Uganda −0.23 (95% CI −0.43 to −0.03) lower in the intervention than in the control arm. In South Africa the mean WLZ at 24 weeks was 0.23 (95% CI 0.03 to 0.43) greater in the intervention than in the control arm. Differences in LAZ between the study arms were small and not statistically significant. In Uganda, infants in the intervention arm were more likely to be wasted compared to those in the control arm at 24 weeks (PR 2.36; 95% CI 1.11 to 5.00). Differences in wasting in South Africa and Burkina Faso and stunting and underweight in all three countries were small and not significantly different.

Conclusions

There were small differences in mean anthropometric indicators between the intervention and control arms in the study, but in Uganda and Burkina Faso, a tendency to slightly lower ponderal growth (weight-for-length z-scores) was found in the intervention arms.

Trial registration number

ClinicalTrials.gov: NCT00397150

【 授权许可】

   
2014 Engebretsen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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