CD4+ lymphocyte adenosine triphosphate - a new marker in sepsis with acute kidney injury?

BMC Nephrology

Michael J Koziolek¹  Gerhard A Müller¹  Simon Schneider¹  Gunnar Brandhorst¹  Maria Brier¹  Malte Heeg¹  Daniel Patschan² 

[1]University Hospital of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany

[2]Department of Nephrology and Rheumatology, University Hospital of Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany

关键词: Kidney regeneration;    Mortality;    AKI;    Sepsis;    ATP_CD4;   

Others  :  1113267
DOI  :  10.1186/1471-2369-15-203

 received in 2014-08-25, accepted in 2014-12-15,  发布年份 2014

【 摘 要 】

Background

AKI frequently develops in sepsis patients, significantly decreasing the overall prognosis. There are currently no diagnostic markers available which reliably predict the prognosis of sepsis-associated AKI. Recently, ATP content of CD4+ T cells (ATP_CD4) has been shown to correlate with survival in sepsis. The aim of the study was to determine ATP_CD4 in sepsis-associated AKI.

Methods

Thirty-three patients with sepsis were prospectively analyzed for ATP_CD4 at three different time points. Results were related to survival, renal recovery, and further clinical/laboratory findings.

Results

ATP_CD4 tended to lower in concentration at 48 h after onset of sepsis in those patients with complete renal recovery. There were no differences between patients with no AKI and those with AKI of different severity (AKIN 1-3). Urinary NGAL did not correlate with renal prognosis.

Conclusion

ATP_CD4 may serve as risk predictor in sepsis-associated AKI. Lower concentrations may indicate a higher chance of complete renal recovery in sepsis.

【 授权许可】

   
2014 Patschan et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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