No evidence for LGV transmission among heterosexuals in Amsterdam, the Netherlands

BMC Research Notes

Maarten F Schim van der Loeff¹  Henry JC de Vries³  Servaas A Morré⁴  Arjen GCL Speksnijder²  Stephan P Verweij⁶  Marlies Heiligenberg⁵ 

[1]Department of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands

[2]Cluster of Infectious Diseases, Public Health Service Amsterdam, P.O. Box 2200, 1000 CE Amsterdam, the Netherlands

[3]Centre for Infectious Diseases Control, National Institute for Public Health and the Environment (Rijksinstituut voor Volksgezondheid en Milieu, RIVM), Postbus 13720 BA Bilthoven, the Netherlands

[4]Department of Genetics and Cell Biology, Institute of Public Health Genomics, Research InstituteGROW, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6202 AZ Maastricht, The Netherlands

[5]Public Health Service Amsterdam, Nieuwe Achtergracht 100, 1018 WT Amsterdam, the Netherlands

[6]Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, the Netherlands

关键词: Chlamydia trachomatis;    Lymphogranuloma venereum (LGV);    Heterosexual;    IgA anti-MOMP;   

Others  :  1132503
DOI  :  10.1186/1756-0500-7-355

 received in 2013-08-30, accepted in 2014-04-29,  发布年份 2014

【 摘 要 】

Background

In recent years a few cases of lymphogranuloma venereum (LGV) in heterosexuals in Europe have been reported. It is not known whether LGV transmission among heterosexuals occurs on a wider scale.

Methods

Heterosexual male and female STI clinic clients (n = 587) in Amsterdam, the Netherlands, with a positive nucleic acid amplification test (NAAT) result for Chlamydia trachomatis (CT) were screened for IgA anti-MOMP in serum. If the value was above the cut-off index (2.0) the patient’s CT positive urogenital, ocular or rectal sample(s) were selected and tested for LGV by an in-house LGV-specific NAAT.

Results

Sera of 126 patients were above 2.0 COI. Some patients had >1 CT positive sample. Samples could not be retrieved from 15 of the 126 persons, and 7 samples that were found positive for CT in the diagnostic amplification process could not be confirmed and hence not typed. We did not find a single case of LGV infection in 123 urogenital, ocular or rectal samples from 104 patients.

Conclusion

We found no indications for significant spread of LGV infection in heterosexuals in Amsterdam. Surveillance in females with cervical or anal CT infection is indicated to monitor LGV occurrence in heterosexuals.

【 授权许可】

   
2014 Heiligenberg et al.; licensee BioMed Central Ltd.

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