The relationship between training status, blood pressure and uric acid in adults and elderly

BMC Cardiovascular Disorders

Anderson Saranz Zago¹  Sandra Lia do Amaral¹  José Eduardo Tanus-Santos²  Jonas Tadeu Cau Sertorio²  Jaqueline Jóice Muniz²  André Mourão Jacomini²  Atila Alexandre Trapé² 

[1]Department of Physical Education Unesp, São Paulo State University, Bauru, SP, Brazil

[2]Faculty of Medicine, University of São Paulo, Ribeirão Preto, SP, Brazil

关键词: Nitric oxide;    Oxidative stress;    Elderly;    Training status;    Uric acid;    Blood pressure;   

Others  :  857640
DOI  :  10.1186/1471-2261-13-44

 received in 2012-10-02, accepted in 2013-06-17,  发布年份 2013

【 摘 要 】

Background

Hypertension can be generated by a great number of mechanisms including elevated uric acid (UA) that contribute to the anion superoxide production. However, physical exercise is recommended to prevent and/or control high blood pressure (BP). The purpose of this study was to investigate the relationship between BP and UA and whether this relationship may be mediated by the functional fitness index.

Methods

All participants (n = 123) performed the following tests: indirect maximal oxygen uptake (VO₂max), AAHPERD Functional Fitness Battery Test to determine the general fitness functional index (GFFI), systolic and diastolic blood pressure (SBP and DBP), body mass index (BMI) and blood sample collection to evaluate the total-cholesterol (CHOL), LDL-cholesterol (LDL-c), HDL-cholesterol (HDL-c), triglycerides (TG), uric acid (UA), nitrite (NO2) and thiobarbituric acid reactive substances (T-BARS). After the physical, hemodynamic and metabolic evaluations, all participants were allocated into three groups according to their GFFI: G1 (regular), G2 (good) and G3 (very good).

Results

Baseline blood pressure was higher in G1 when compared to G3 (+12% and +11%, for SBP and DBP, respectively, p<0.05) and the subjects who had higher values of BP also presented higher values of UA. Although UA was not different among GFFI groups, it presented a significant correlation with GFFI and VO₂max. Also, nitrite concentration was elevated in G3 compared to G1 (140±29 μM vs 111± 29 μM, for G3 and G1, respectively, p<0.0001). As far as the lipid profile, participants in G3 presented better values of CHOL and TG when compared to those in G1.

Conclusions

Taking together the findings that subjects with higher BP had elevated values of UA and lower values of nitrite, it can be suggested that the relationship between blood pressure and the oxidative stress produced by acid uric may be mediated by training status.

【 授权许可】

   
2013 Trapé et al.; licensee BioMed Central Ltd.

【 图 表 】

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