Effect of physical training on airway inflammation in animal models of asthma: a systematic review

BMC Pulmonary Medicine

Smita Pakhale¹  Lucy Turner²  Andrew Burkett³  Vanessa Luks³ 

[1] Divison of Respirology, The Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada;The Ottawa Hospital Research Institute, Ottawa, Canada;Division of Respirology, The Ottawa Hospital, University of Ottawa, Ottawa, Canada

关键词: Systematic review;    Asthma therapy;    Physical exercise;    Chronic airway inflammation;   

Others  :  1122353
DOI  :  10.1186/1471-2466-13-24

 received in 2012-11-26, accepted in 2013-03-27,  发布年份 2013

【 摘 要 】

Background

There is little data on the effect of exercise on markers of airway inflammation in human asthmatics. The main objective of this review is to determine the effects of physical training on markers of airway inflammation in animal models of asthma.

Methods

A peer reviewed search was applied to Medline, Embase, Web of Science, Cochrane, and DARE databases. Data extraction was performed in a blinded fashion.

Results

From the initial 2336 studies, a total of 10 studies were selected for the final analysis. All were randomized controlled trials with low to moderate intensity training on ovalbumin-sensitized mice. In the exercised group of mice, there was a reduction in BAL eosinophils and Th-2 cytokines, no change in Th-1 cytokines, an increase in IL-10, and a reversal of airway remodeling. The data was not pooled owing to significant heterogeneity between studies, and a funnel plot test for publication bias was not performed because there were few studies reporting on any one outcome measure. The asthma models differed between studies in age and gender of mice, as well as in timing of physical training after sensitization. The risk of bias was unclear for some studies though this may not influence outcome measures. The accuracy of data extracted from graphics is unknown.

Conclusions

Physical training improves airway inflammation in animal asthma models.

【 授权许可】

   
2013 Luks et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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