Antidiabetic activities of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin-induced diabetic rats

BMC Complementary and Alternative Medicine

Sirichai Adisakwattana⁵  Asfaw Debella²  Yelamtsehay Mekonnen¹  Eyasu Makonnen³  Alemayehu Toma⁴ 

[1] Department of Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Directorate of Traditional and Modern Drug Research, Ethiopian Public Health Institute (EPHI, Addis Ababa, Ethiopia;Pharmacology Department, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia;Pharmacology Unit, School of Medicine, Hawassa University, Hawassa, Ethiopia;Department of Nutrition and Dietetics, Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan 10330, Bangkok, Thailand

关键词: Histopathology;    Moringa stenopetala;    Streptozotocin;    Antihyperlipidemic;    Antihyperglycemic;   

Others  :  1219981
DOI  :  10.1186/s12906-015-0779-0

 received in 2015-04-27, accepted in 2015-07-13,  发布年份 2015

【 摘 要 】

Background

Moringa stenopetala has been used in traditional health systems to treat diabetes mellitus. The aim of this study was to investigate the antidiabetic activity of aqueous ethanol and n-butanol fraction of Moringa stenopetala leaves in streptozotocin (STZ) induced diabetic rats.

Methods

The aqueous ethanol extract and n-butanol fraction of Moringa stenopetala leaves hydroalcoholic (500 mg/kg body weight) and metformin (150 mg/kg body weight) were administered to diabetic rats. Blood glucose, lipid profiles, liver and kidney function were examined after 14 days of experiment. Histopathological profile of the pancreas was also observed in diabetic rats at the end of study. An oral sucrose challenge test was also carried out to assess the post prandial effect of the extract.

Results

Oral administration of the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves (500 mg/kg body weight) and metformin (150 mg/kg) significantly reduced blood glucose level (P < 0.05), improved serum lipid profiles, liver enzymes and kidney functions in diabetic rats after 14 days. The extracts also improved damage of islet of Langerhan’s in diabetic rats. The plant material reduced the post-prandial glucose level (P < 0.001) at the dose of 750 mg/kg.

Conclusion

These findings revealed that both the aqueous ethanol and n-butanol extracts of Moringa stenopetala leaves possess antihyperglycemic and antihyperlipidemic properties, and alleviate STZ-induced pancreatic damage in diabetic rats. The beneficial effects of plant material in inhibition of diabetes-induced complications are being investigated.

【 授权许可】

   
2015 Toma et al.

【 图 表 】

Fig. 1.

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