Incidence of viral respiratory infections in a prospective cohort of outpatient and hospitalized children aged ≤5 years and its associated cost in Buenos Aires, Argentina

BMC Infectious Diseases

Marcela Echavarria²  Guadalupe Carballal²  Jorge Ekstrom¹  Santiago Vidaurreta¹  Eduardo Azziz-Baumgartner³  Lizette O. Durand³  Débora Natalia Marcone² 

[1]Department of Pediatrics, Centro de Educación Médica e Investigaciones Clínicas “CEMIC”, Buenos Aires, Argentina

[2]Virology Unit and Clinical Virology Laboratory, Centro de Educación Médica e Investigaciones Clínicas “CEMIC” and CONICET, Galván 4102, Buenos Aires, 1431 FWO, Argentina

[3]Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A32, Atlanta GA 30329-4018, Georgia, USA

关键词: Charges;    Hospitalized and outpatients;    Influenza;    Respiratory syncytial virus;    Rhinovirus;    Children;    Incidence;   

Others  :  1232854
DOI  :  10.1186/s12879-015-1213-4

 received in 2015-03-25, accepted in 2015-10-13,  发布年份 2015

【 摘 要 】

Background

Although information about the incidence of viral respiratory illnesses and their associated cost can help health officials explore the value of interventions, data are limited from middle-income countries.

Methods

During 2008–2010, we conducted a prospective cohort study and followed ~1,800 Argentinian children aged ≤5 years to identify those children who were hospitalized or who sought care at an emergency room with any acute respiratory infection sign or symptom (e.g., rhinorrhea, cough, wheezing, tachypnea, retractions, or cyanosis). Respiratory samples were obtained for respiratory syncytial virus, influenza, parainfluenza, adenovirus, and metapneumovirus testing by immunofluorescence and for rhinovirus by real-time reverse transcription polymerase chain reaction.

Results

The incidence of respiratory syncytial virus (24/1000 children-years), human metapneumovirus (8/1000 children-years), and influenza (8/1000 children-years) illnesses was highest among hospitalized children aged <6 months and decreased among older children. In contrast, the incidence of rhinovirus was highest (12/1000 children-years) among those aged 6–23 months. In the emergency room, the incidence of rhinovirus was 459; respiratory syncytial virus 352; influenza 185; parainfluenza 177; metapneumovirus 130; and adenovirus 73/1,000 children-years. The total cost of hospitalization was a median of US$529 (Interquartile range, US$362–789).

Conclusions

Our findings indicate that respiratory viruses, in particular rhinovirus, respiratory syncytial virus, metapneumovirus, and influenza may be associated with severe illness causing substantial economic burden.

【 授权许可】

   
2015 Marcone et al.

【 图 表 】

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