Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder

BMC Psychiatry

Gregory McCarthy⁴  Florin Dolcos³  Heidi J Munger²  Michael A Hauser²  Andrea L Gold⁴  Ahmad R Hariri⁵  Rajendra A Morey¹ 

[1] Mid-Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Durham, NC 27705 USA;Center for Human Genetics, Duke University, Durham, NC 27710 USA;Department of Psychology, Neuroscience Program, and Beckman Institute for Advanced Science & Technology, University of Illinois, Urbana-Champaign, IL, USA;Department of Psychology, Yale University, New Haven, CT 06520 USA;Department of Psychology & Neuroscience, and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708 USA

关键词: cognitive control;    emotion processing;    working memory;    rs16965628;    SLC6A4;    amygdala;    ventrolateral PFC;    imaging genetics;    PTSD;   

Others  :  1124560
DOI  :  10.1186/1471-244X-11-76

 received in 2010-12-24, accepted in 2011-05-05,  发布年份 2011

【 摘 要 】

Background

Serotonergic system dysfunction has been implicated in posttraumatic stress disorder (PTSD). Genetic polymorphisms associated with serotonin signaling may predict differences in brain circuitry involved in emotion processing and deficits associated with PTSD. In healthy individuals, common functional polymorphisms in the serotonin transporter gene (SLC6A4) have been shown to modulate amygdala and prefrontal cortex (PFC) activity in response to salient emotional stimuli. Similar patterns of differential neural responses to emotional stimuli have been demonstrated in PTSD but genetic factors influencing these activations have yet to be examined.

Methods

We investigated whether SLC6A4 promoter polymorphisms (5-HTTLPR, rs25531) and several downstream single nucleotide polymorphisms (SNPs) modulated activity of brain regions involved in the cognitive control of emotion in post-9/11 veterans with PTSD. We used functional MRI to examine neural activity in a PTSD group (n = 22) and a trauma-exposed control group (n = 20) in response to trauma-related images presented as task-irrelevant distractors during the active maintenance period of a delayed-response working memory task. Regions of interest were derived by contrasting activation for the most distracting and least distracting conditions across participants.

Results

In patients with PTSD, when compared to trauma-exposed controls, rs16965628 (associated with serotonin transporter gene expression) modulated task-related ventrolateral PFC activation and 5-HTTLPR tended to modulate left amygdala activation. Subsequent to combat-related trauma, these SLC6A4 polymorphisms may bias serotonin signaling and the neural circuitry mediating cognitive control of emotion in patients with PTSD.

Conclusions

The SLC6A4 SNP rs16965628 and 5-HTTLPR are associated with a bias in neural responses to traumatic reminders and cognitive control of emotions in patients with PTSD. Functional MRI may help identify intermediate phenotypes and dimensions of PTSD that clarify the functional link between genes and disease phenotype, and also highlight features of PTSD that show more proximal influence of susceptibility genes compared to current clinical categorizations.

【 授权许可】

   
2011 Morey et al; licensee BioMed Central Ltd.

【 图 表 】

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