BMC Nephrology | |
EBV-positive diffuse large B-cell lymphoma in a patient with primary Sjögren’s syndrome and membranous glomerulonephritis | |
Soo Wan Kim1  Seong Kwon Ma1  Eun Hui Bae1  Joon Seok Choi1  Yoo Duk Choi2  Chang Seong Kim1  | |
[1] Department of Internal Medicine, Chonnam National University Medical School, 42 Jebongro, Gwangju, 501-757, South Korea;Department of pathology, Chonnam National University Medical School, Gwangju, South Korea | |
关键词: EBV-positive diffuse large B-cell lymphoma; Membranous glomerulonephritis; Primary Sjögren’s syndrome; | |
Others : 1083062 DOI : 10.1186/1471-2369-13-149 |
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received in 2012-02-24, accepted in 2012-11-08, 发布年份 2012 | |
【 摘 要 】
Background
Sjögren’s syndrome is a systemic autoimmune disease in which lymphatic cells destroy the salivary and lacrimal glands. Glomerulonephritis is thought to be a rare occurrence in primary Sjögren’s syndrome. Furthermore, concurrent glomerular involvement and lymphoma in patients with Sjögren’s syndrome has seldom been reported.
Case presentation
A 52-year-old woman with primary Sjögren’s syndrome developed membranous glomerulonephritis and Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL). She was diagnosed with Sjögren’s syndrome based on the dry eyes, dry mouth, positive anti-nuclear antibody test, anti-Ro (SS-A) antibody, salivary gland biopsy, and salivary scintigraphy. Moreover, renal biopsy confirmed the diagnosis of membranous glomerulonephritis. Three months later, her small bowel was perforated with pneumoperitoneum, and the biopsy revealed Epstein-Barr virus-positive DLBCL.
Conclusions
We observed the first case of primary Sjögren’s syndrome associated with Epstein-Barr Virus-positive DLBCL and membranous glomerulonephritis. Because of the possibility of malignancy-associated membranous glomerulonephritis in patients with primary Sjögren’s syndrome, we should be careful and examine such patients for hidden malignancy.
【 授权许可】
2012 Kim et al.; licensee BioMed Central Ltd.
【 预 览 】
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Figure 1. | 54KB | Image | download |
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