Glucose–insulin–potassium therapy in patients with acute coronary syndrome: a meta-analysis of randomized controlled trials

BMC Cardiovascular Disorders

Qin-Fu Han²  Wei-Fang Liang²  Xiao-Yan Guo²  Hai-San Zhang¹  Pei-Yin Jin² 

[1] The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, Henan, China;Department of Cardiovascular Medicine, The People’s Hospital of Anyang, Anyang, Henan, China

关键词: Meta-analysis;    Acute coronary syndrome;    Glucose–insulin–potassium;   

Others  :  1088672
DOI  :  10.1186/1471-2261-14-169

 received in 2014-09-05, accepted in 2014-11-18,  发布年份 2014

【 摘 要 】

Background

Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess whether the use of GIK infusions >3 or <3 hours after the onset of symptoms reduce mortality or cardiac arrest.

Methods

Electronic databases (Medline, EMBASE, and Cochrane Central Register of Controlled Trials) and references of retrieved articles were searched for RCTs evaluating the effect of GIK infusions, <3 hours or >3 hours after the onset of symptoms, on mortality and/or cardiac arrest. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each outcome.

Results

Nine trials were identified and eligible for review. The summary OR for in-hospital mortality was 1.01 (95% CI 0.94 to 1.09), based on 2,542 deaths among 27,294 patients. The subgroup analysis according to the study enrollment time (within 3 hours [OR, 0.77, 95% CI 0.50-1.16], vs. >3 hours [OR, 0.90; 95% CI, 0.67-1.21]) did not reveal any difference in mortality.

Conclusions

Administration of GIK in ACS patients does not significantly reduce mortality whether or not GIK administration >3 or <3 hours after the onset of symptoms.

【 授权许可】

   
2014 Jin et al.; licensee BioMed Central Ltd.

【 图 表 】

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