Oxidative stress in schizophrenia: a case–control study on the effects on social cognition and neurocognition

BMC Psychiatry

Martin Brüne³  Aysen Esen-Danaci²  Omer Aydemir²  Zeynep Cubukcoglu²  Ece Onur¹  Soner Erdin¹  Elliot C Brown⁵  Cumhur Tas⁴  Cristina Gonzalez-Liencres³ 

[1] Department of Biochemistry, Celal Bayar University, Manisa, Turkey;Department of Psychiatry, Celal Bayar University, Manisa, Turkey;Division of Cognitive Neuropsychiatry and Psychiatric Preventative Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinensr. 1-3, Bochum, 44791, Germany;Department of Psychology, Uskudar University, İstanbul, Turkey;Maryland Psychiatric Research Centre, University of Maryland School of Medicine, Baltimore, MD, USA

关键词: Working memory;    Executive functioning;    Emotion recognition;    Theory of mind;    Reactive oxygen species;    Superoxide dismutase;    Nitric oxide;    Malondialdehyde;    Glutathione;    Neurotrophin 5;    Neurotrophin 4;   

Others  :  1123326
DOI  :  10.1186/s12888-014-0268-x

 received in 2014-06-06, accepted in 2014-09-11,  发布年份 2014

【 摘 要 】

Background

Schizophrenia is a debilitating mental disorder that presents impairments in neurocognition and social cognition. Several studies have suggested that the etiology of schizophrenia can be partly explained by oxidative stress. However, our knowledge about the implications of oxidative stress on illness-related cognitive deficits is still far from being clear. The aim of this work was to study the role of oxidative stress molecules on social cognition and neurocognition in patients with schizophrenia.

Methods

We assessed the peripheral levels of several molecules associated with oxidative stress, namely nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), homocysteine, superoxide dismutase (SOD) and neurotrophin 4/5 (NT4/5), in forty–one patients with schizophrenia and forty-three healthy participants. A battery of tests to measure neurocognition and social cognition was also administered to the schizophrenia group.

Results

We found that the schizophrenia group presented substantially higher levels of oxidative stress than the control group, as revealed by elevated quantities of the pro-oxidants NO and MDA, and decreased levels of the antioxidants GSH, SOD and NT4/5. Interestingly, the levels of NT4/5, which have been shown to have antioxidant effects, correlated with executive functioning, as measured by two distinct tests (WCST and TMT). However, social cognition and symptom severity were not found to be associated with oxidative stress.

Conclusions

We propose a protective role of NT4/5 against oxidative stress, which appears to have a potentially beneficial impact on neurocognition in schizophrenia.

【 授权许可】

   
2014 Gonzalez-Liencres et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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