期刊论文详细信息
BMC Infectious Diseases
Effects of campaign for postpartum vaccination on seronegative rate against rubella among Japanese women
Hisanori Minakami6  Shigeki Matsubara3  Nobuya Unno1  Shigeru Saito4  Akihito Nakai5  Takahiko Kubo2  Mika Ito4  Akihide Ohkuchi3  Eriko Hashimoto5  Masachi Hanaoka1  Junko Mochizuki2  Takahiro Yamada6 
[1] Department of Maternal-Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan;Department of Obstetric and Gynecology, School of Medicine, Kitasato University, Sagamihara, Japan;Department of Obstetric and Gynecology, Jichi Medical University School of Medicine, Shimotsuke, Japan;Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani, Japan;Department of Obstetric and Gynecology, Nippon Medical School, Tokyo, Japan;Department of Obstetrics, Hokkaido University Graduate School of Medicine, N15W7, Kita-ku, Sapporo 060-8638, Japan
关键词: Vaccine;    Outbreak;    Congenital rubella syndrome;   
Others  :  1134303
DOI  :  10.1186/1471-2334-14-152
 received in 2013-11-21, accepted in 2014-03-18,  发布年份 2014
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【 摘 要 】

Background

Japan experienced two rubella outbreaks in the past decade (2004 and 2012 – 2013), resulting in 10 and 20 infants with congenital rubella syndrome (CRS), respectively. This study was performed to determine whether the seronegative rate was lower in multiparous women than in primiparous women in Japan.

Methods

Hemagglutination inhibition (HI) test results during pregnancy were analyzed retrospectively in 11048 primiparous and 9315 multiparous women who gave birth at six hospitals in northern Japan in the 5-year study period (January 2008 through December 2012). Women with HI titer <  1:8 were defined as susceptible to rubella.

Results

The seronegative rate was significantly lower in multiparous than primiparous women aged 30 – 31 years (2.3% [22/967] vs. 4.5% [66/1454], P  =  0.0036), 36 – 37 years (3.4% [55/1601] vs. 5.7% [79/1389], P  =  0.0030), and overall women (3.8% [350/9315] aged 34.7  ±  5.2 vs. 5.4% [597/11048] for 33.2  ±  5.9, P  <  0.001). The susceptible fraction size did not differ largely according to hospital, ranging from 3.5% to 6.3%. Those for each year did not change markedly; 4.5% [150/3369], 5.2% [221/4268], 4.4% [195/4412], 4.6% [186/4056], and 4.6% [195/4258] for 2008, 2009, 2010, 2011, and 2012, respectively. Those for teenagers were consistently high: 22.7% [5/22], 20.7% [6/29], 20.6% [7/34], 13.0% [3/23], and 23.5% [4/17] for 2008, 2009, 2010, 2011, and 2012, respectively.

Conclusions

The seronegative rate was significantly lower in multiparous than primiparous women. However, Japanese rubella vaccination programs were insufficient to eliminate CRS.

【 授权许可】

   
2014 Yamada et al.; licensee BioMed Central Ltd.

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