Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials

BMC Medicine

Fabrice Andre¹  Pernelle Lavaud² 

[1]Université Paris Sud, Faculté de Médecine, Kremlin Bicêtre, France

[2]Department of Medical Oncology, Gustave Roussy Cancer Center, Villejuif, France

关键词: Monoclonal antibodies;    Tyrosine kinase inhibitors;    Resistance;    HER-2;    Breast cancer;   

Others  :  1121553
DOI  :  10.1186/s12916-014-0132-3

 received in 2014-05-02, accepted in 2014-07-17,  发布年份 2014

【 摘 要 】

Breast cancers over-express the human epidermal growth factor receptor 2 (HER2) in about 15% of patients. This transmembrane tyrosine kinase receptor activates downstream signaling pathways and leads to proliferation of cancer cells. Trastuzumab, an anti-HER2 monoclonal antibody, improves outcome in women with early and metastatic breast cancer. Resistance to trastuzumab involves the phosphoinositide 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, truncation of the Her2 receptor or lack of immune response. The last decade has seen major advances in strategies to overcome resistance to trastuzumab. This includes the development of antibody-drug conjugates, dual HER2 inhibition strategies, inhibition of PI3K/mTOR pathway and development of modulators of immune checkpoints.

【 授权许可】

   
2014 Lavaud and Andre; licensee BioMed Central

【 图 表 】

Figure 1.

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