Different K CO and V A combinations exist for the same DL CO value in patients with diffuse parenchymal lung diseases

BMC Pulmonary Medicine

Dominique Israël-Biet³  Christophe Delclaux⁵  Hilario Nunes⁶  Raphaël Borie²  Carole Planes⁴  Laurent Plantier¹  Jean Pastre³ 

[1] Université Paris Diderot, Sorbonne Paris Cité and AP-HP, Service de Physiologie, Hôpital Bichat-Claude Bernard, Paris, France;Université Paris Descartes, Sorbonne Paris Cité and AP-HP, Service de Pneumologie, Hôpital Bichat-Claude Bernard, Paris, France;Université Paris Descartes, Sorbonne Paris Cité and AP-HP, Service de Pneumologie, Hôpital Européen Georges Pompidou, Paris, France;Université Paris 13, Sorbonne Paris Cité and AP-HP, Service de Physiologie, Hôpital Avicenne, Bobigny, France;Université Paris Descartes, Sorbonne Paris Cité and AP-HP, Service de Physiologie, Hôpital Européen Georges Pompidou, Paris, France;Université Paris 13, Sorbonne Paris Cité and AP-HP, Service de Pneumologie, Hôpital Avicenne, Bobigny, France

关键词: Interstitial lung disease;    KCO;    Carbon monoxide transfer coefficient;    DLCO;    Carbon monoxide diffusing capacity;   

Others  :  1224062
DOI  :  10.1186/s12890-015-0084-1

 received in 2015-01-23, accepted in 2015-07-29,  发布年份 2015

【 摘 要 】

Background

DL _COis the product of the CO transfer coefficient (K _CO ) by the “accessible” alveolar volume (V _A ). In theory, the same DL _COmay result from various combinations of K _COand V _Avalues, each of which reflect different injury sites and mechanisms. We sought to determine in this study the potential variability of both V _Aand K _COfor fixed values of DL _COin diffuse parenchymal lung diseases (DPLD).

Methods

To this end, we designed a retrospective, cross-sectional study of three distinct types of DPLD and analysed pulmonary function test (PFT) datasets.

Results

We show here that for the same value of DL _CO(50 % predicted), K _COvaried from 60 to 95 % predicted and V _Afrom 55 to 85 % predicted in various types of DPLD idiopathic pulmonary fibrosis, sarcoidosis and connective tissue disease-associated DPLD, indicating distinct pathogenic mechanisms in these diseases. In addition, a comparison of V _Awith total lung capacity may help to evidence the distal airway obstruction sometimes associated with certain DPLD particularly sarcoidosis.

Conclusion

Clinicians should take into account not only DL _CObut also V _Aand K _COvalues when managing patients with DPLD.

【 授权许可】

   
2015 Pastre et al.

【 图 表 】

Fig. 1.

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