Granulicatella bacteraemia in children: two cases and review of the literature

BMC Pediatrics

Patrizia D’Argenio³  Francesca Ippolita Calò Carducci³  Paola Bernaschi¹  Gabriele Rinelli²  Maria Assunta Castelluzzo³  Sara Chiurchiù³  Donato Amodio³  Maia De Luca³ 

[1] Unit of Microbiology, Department of Laboratories, Bambino Gesù Children’s Hospital, Piazza Sant’Onofrio 4, Rome, Italy;Unit of Cardiology, Bambino Gesù Children’s Hospital, Piazza Sant’Onofrio 4, Rome, Italy;Unit of Immunology and Infectious Disease, University Hospital Pediatric Department, Bambino Gesù Children’s Hospital, Piazza Sant’Onofrio 4, Rome, Italy

关键词: Paediatrics;    Meropenem;    Treatment;    NVS;    Bacteremia;    Endocarditis;    Granulicatella;   

Others  :  1144966
DOI  :  10.1186/1471-2431-13-61

 received in 2012-06-07, accepted in 2013-04-11,  发布年份 2013

【 摘 要 】

Background

Granulicatella spp. is a fastidious bacteria responsible for bacteremia and endocarditis which are fatal in about 20% of the cases. These severe infections are uncommon in children under 17 years of age and have proven extremely difficult to treat.

Cases presentation

We report a brief review of the literature and two cases of NVS bacteremia by Granulicatella complicated by infective endocarditis (IE). The first one is that of a 7-year-old Caucasian female with Shone syndrome and IE involving the pulmonary valve homograft, confirmed by echocardiography. The second case is that of a 5-year-old Caucasian male. In this patient echocardiogram was negative for signs of IE; however, a “possible” IE was suspected on the basis of a cardiac catheterization 3 weeks before the onset of fever. Since in both our patients clinical failure of first line antibiotic treatment was observed, we used a combination of meropenem with another anti-streptococcal drug with excellent results.

Conclusion

In Granulicatella bacteremia in the pediatric population, combination antimicrobial therapy including meropenem should be considered as a second line treatment in non-responding patients.

【 授权许可】

   
2013 De Luca et al.; licensee BioMed Central Ltd.

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