Sleep-related breathing disorders and gait variability: a cross-sectional preliminary study

BMC Pulmonary Medicine

Olivier Beauchet²  Frédéric Roche⁴  Jean-Claude Barthélémy⁴  Richard Camicioli³  Cédric Annweiler¹  Sébastien Celle⁴ 

[1] Center for Functional and Metabolic Mapping, Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada;Department of Neuroscience, Division of Geriatric Medicine, UPRES EA 4638, UNAM, Angers University Hospital, 49933 Angers, Cedex 9, France;Department of Medicine, Glenrose Rehabilitation Hospital, University of Alberta, Edmonton, Alberta, Canada;Service de Physiologie Clinique et de l’Exercice, CHU Saint-Etienne; EA 4607 “SNA EPIS” Faculté de Médecine Jacque Lisfranc UJM, PRES Université de Lyon, Lyon 42023, France

关键词: Older adults;    Sleep-related breathing disorders;    Gait disorders;   

Others  :  1109540
DOI  :  10.1186/1471-2466-14-140

 received in 2014-02-28, accepted in 2014-08-18,  发布年份 2014

【 摘 要 】

Background

Sleep-related breathing disorders (SRBDs) provoke cognitive and structural brain disorders. Because these disorders have been associated with unsafe gait characterized by an increase in stride-to-stride variability of stride time (STV), we hypothesised that SRBDs could be associated with an increased STV. The aim of this study was to examine the association between SRBDs and STV in French healthy older community-dwellers.

Methods

A total of 49 participants (mean age 69.6 ± 0.8years; 65.2% female) were included in this cross-sectional study. All participants, who were free of clinically diagnosed SRBDs before their inclusion, had a nocturnal unattended home-sleep assessment. There were separated in three group based on apnea + hypopnea index (AHI): AHI <15 defining the absence of SRBD, AHI between 15–30 defining mild SRBD, and AHI >30 defining moderate-to-severe SRBD. Coefficient of variation of stride time, which is a measure of STV, was recorded while usual walking using SMTEC® footswitches system. Digit span score was used as a measure of executive performance. Age, gender, body mass index (BMI), number of drugs daily taken, vision, proprioception, history of falls, depression symptoms, global cognitive functioning were also recorded.

Results

STV and BMI were higher in participants with mild SRBDs (P = 0.031 and P = 0.020) and moderate-to-severe SRBDs (P = 0.004 and P = 0.002) compared to non-SRBDs. STV positively correlated with AHI (P = 0.036). Lower (i.e., better) STV was associated with the absence of SRBDs (P = 0.021), while greater (i.e., worse) STV was associated with moderate-to-severe SRBD (P < 0.045) but not with mild SRBD (P > 0.06).

Conclusion

Our results show a positive association between STV and SRBDs, with moderate-to-severe SRBD being associated with greater gait variability. This association opens new perspectives for understanding gait disorders in older adults with SRBDs and opens the door to treatments options since SRBDs are potential treatable factors.

【 授权许可】

   
2014 Celle et al.; licensee BioMed Central Ltd.

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