Predictors of non-transplantation of adult donor organs - an observational study using routine data from Eurotransplant

BMC Health Services Research

Christian Joachim Apfelbacher¹  Julika Loss¹  Martin Loss²  Karl Philipp Drewitz¹ 

[1] Medical Sociology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Dr.-Gessler-Str. 17, Regensburg, 93051, Germany;Department of Surgery, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, 93051, Germany

关键词: Donor organ allocation;    Donor factors;    Pancreas transplantation;   

Others  :  1090986
DOI  :  10.1186/s12913-014-0584-3

 received in 2014-01-24, accepted in 2014-11-07,  发布年份 2014

【 摘 要 】

Background

The majority of pancreases, offered in allocation, are not transplanted. This pancreas under-utilisation is a phenomenon observed in all transplant systems in North-America and Europe. It was the aim of this study to analyse factors predictive of pancreas non-transplantation in Germany.

Methods

Routine Eurotransplant data of 3,666 deceased German donors (from 2002–2011) were used for multivariate modelling. Socio-demographic and medical factors were considered as independent variables in logistic regression models with non-transplantation as dependent variable.

Results

Male gender, advanced age, overweight/obesity, long ICU stay, a history of smoking, non-traumatic brain death, elevated levels of sodium, serum glucose, lipase/amylase and the liver not being considered for procurement were significant independent predictors of non-transplantation.

Conclusion

In line with previous research, advanced age, high BMI, long ICU stay and the liver not being considered for procurement were the strongest predictors of pancreas non-transplantation in Germany. About three quarters of the variance remained unexplained, suggesting that factors not assessed or unknown may play a decisive role.

【 授权许可】

   
2014 Drewitz et al.; licensee BioMed Central Ltd.

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