Reference Ranges for Bone Mineral Density and Prevalence of Osteoporosis in Vietnamese Men and Women

BMC Musculoskeletal Disorders

Tuan V Nguyen¹  Nguyen D Nguyen⁴  Hoa N Pham⁵  Uyen D TNguyen³  Lan T Ho-Pham² 

[1] St Vincent's Clinical School, Victoria Street, Sydney NSW 2010, Australia; 6School of Public Health and Community Medicine, University of New South Wales, NSW 2052, Australia;Department of Rheumatology, People's Hospital 115, 88 Thanh Thai Street, Ward 12, District 10, Ho Chi Minh City, Vietnam;Department of Internal Medicine, Pham Ngoc Thach University of Medicine, 86/2 Thanh Thai St, Ward 12, District 10, Ho Chi Minh City, Vietnam;Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, 384 Victoria Street, Sydney NSW 2010, Australia;Department of Nuclear Medicine, Cho Ray Hospital, 201B Nguyen Chi Thanh Street, District 5, Ho Chi Minh City, Vietnam

关键词: men;    women;    osteoporosis;    bone mineral density;    reference range;   

Others  :  1152490
DOI  :  10.1186/1471-2474-12-182

 received in 2011-05-24, accepted in 2011-08-10,  发布年份 2011

【 摘 要 】

Background

The aim of this study was to examine the effect of different reference ranges in bone mineral density on the diagnosis of osteoporosis.

Methods

This cross-sectional study involved 357 men and 870 women aged between 18 and 89 years, who were randomly sampled from various districts within Ho Chi Minh City, Vietnam. BMD at the femoral neck, lumbar spine and whole body was measured by DXA (Hologic QDR4500). Polynomial regression models and bootstraps method were used to determine peak BMD and standard deviation (SD). Based on the two parameters, we computed T-scores (denoted by T_VN) for each individual in the study. A similar diagnosis was also done based on T-scores provided by the densitometer (T_DXA), which is based on the US White population (NHANES III). We then compared the concordance between T_VN and T_DXA in the classification of osteoporosis. Osteoporosis was defined according to the World Health Organization criteria.

Results

In post-menopausal women, the prevalence of osteoporosis based on femoral neck T_VN was 29%, but when the diagnosis was based on T_DXA, the prevalence was 44%. In men aged 50+ years, the T_VN-based prevalence of osteoporosis was 10%, which was lower than T_DXA-based prevalence (30%). Among 177 women who were diagnosed with osteoporosis by T_DXA, 35% were actually osteopenia by T_VN. The kappa-statistic was 0.54 for women and 0.41 for men.

Conclusion

These data suggest that the T-scores provided by the Hologic QDR4500 over-diagnosed osteoporosis in Vietnamese men and women. This over-diagnosis could lead to over-treatment and influence the decision of recruitment of participants in clinical trials.

【 授权许可】

   
2011 Ho-Pham et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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