Lateral frontal cortex volume reduction in Tourette syndrome revealed by VBM

BMC Neuroscience

Kirsten R Müller-Vahl⁴  Reinhard Dengler⁵  Hartmut Becker¹  Nadine Buddensiek⁴  Alexander Glahn⁴  Julian Grosskreutz²  Thomas Peschel⁴  Sarah Bornmann⁴  Matthias Wittfoth³ 

[1] Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany;Department of Neurology, University of Jena, Jena, Germany;NeuroImaging and Clinical Applications (NICA), Hannover, Germany;Clinic of Psychiatry, Socialpsychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany;Department of Neurology, Hannover Medical School, Hannover, Germany

关键词: Attention deficit hyperactivity disorder;    Obsessive-compulsive disorder;    Amygdala;    Inferior frontal gyrus;    Voxel-based morphometry;    Gilles de la Tourette syndrome;   

Others  :  1170840
DOI  :  10.1186/1471-2202-13-17

 received in 2011-09-20, accepted in 2012-02-14,  发布年份 2012

【 摘 要 】

Background

Structural changes have been found predominantly in the frontal cortex and in the striatum in children and adolescents with Gilles de la Tourette syndrome (GTS). The influence of comorbid symptomatology is unclear. Here we sought to address the question of gray matter abnormalities in GTS patients with co-morbid obsessive-compulsive disorder (OCD) and/or attention deficit hyperactivity disorder (ADHD) using voxel-based morphometry (VBM) in twenty-nine adult actually unmedicated GTS patients and twenty-five healthy control subjects.

Results

In GTS we detected a cluster of decreased gray matter volume in the left inferior frontal gyrus (IFG), but no regions demonstrating volume increases. By comparing subgroups of GTS with comorbid ADHD to the subgroup with comorbid OCD, we found a left-sided amygdalar volume increase.

Conclusions

From our results it is suggested that the left IFG may constitute a common underlying structural correlate of GTS with co-morbid OCD/ADHD. A volume reduction in this brain region that has been previously identified as a key region in OCD and was associated with the active inhibition of attentional processes may reflect the failure to control behavior. Amygdala volume increase is discussed on the background of a linkage of this structure with ADHD symptomatology. Correlations with clinical data revealed gray matter volume changes in specific brain areas that have been described in these conditions each.

【 授权许可】

   
2012 Wittfoth et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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