Alcohol intake, wine consumption and the development of depression: the PREDIMED study

BMC Medicine

Miguel A Martínez-González²  Lluis Serra-Majem⁸  Xavier Pintó²  Julia Wärnberg⁷  Rosa-María Lamuela-Raventós²  José Lapetra²  Fernando Arós²  Miquel Fiol²  Dolores Corella²  María-Isabel Covas⁴  Enrique Gómez-Gracia⁷  Pilar Buil-Cosiales³  Jordi Salas-Salvadó⁵  Almudena Sánchez-Villegas⁸  Ramón Estruch¹  Juan J Beunza⁹  Alfredo Gea⁶ 

[1]Department of Internal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain

[2]CIBER Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain

[3]Spain Primary Care, Servicio Navarro de Salud, Osasunbidea, Pamplona, Spain

[4]Lipids and Cardiovascular Epidemiology Research Unit, Institut Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain

[5]Human Nutrition Unit, IISPV, Universitat Rovira i Virgili, Reus, Spain

[6]Department of Preventive Medicine and Public Health, Medical School-Clinica Universidad de Navarra, Pamplona, Spain

[7]Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Málaga, Málaga, Spain

[8]Department of Clinical Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

[9]School of Medicine, Universidad Europea de Madrid, Madrid, Spain

关键词: Cohort;    Depression;    Alcohol;    Wine;   

Others  :  856934
DOI  :  10.1186/1741-7015-11-192

 received in 2013-04-10, accepted in 2013-07-26,  发布年份 2013

【 摘 要 】

Background

Alcoholic beverages are widely consumed. Depression, the most prevalent mental disorder worldwide, has been related to alcohol intake. We aimed to prospectively assess the association between alcohol intake and incident depression using repeated measurements of alcohol intake.

Methods

We followed-up 5,505 high-risk men and women (55 to 80 y) of the PREDIMED Trial for up to seven years. Participants were initially free of depression or a history of depression, and did not have any history of alcohol-related problems. A 137-item validated food frequency questionnaire administered by a dietician was repeated annually to assess alcohol intake. Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression, and/or initiated the use of antidepressant drugs. Cox regression analyses were fitted over 23,655 person-years.

Results

Moderate alcohol intake within the range of 5 to 15 g/day was significantly associated with lower risk of incident depression (hazard ratio (HR) and 95% confidence interval (95% CI) = 0.72 (0.53 to 0.98) versus abstainers). Specifically, wine consumption in the range of two to seven drinks/week was significantly associated with lower rates of depression (HR (95% CI) = 0.68 (0.47 to 0.98)).

Conclusions

Moderate consumption of wine may reduce the incidence of depression, while heavy drinkers seem to be at higher risk.

【 授权许可】

   
2013 Gea et al.; licensee BioMed Central Ltd.

【 图 表 】

【 参考文献 】

• [1]WHO Global Status Report on Alcohol and Health 2011http://www.who.int/substance_abuse/publications/global_alcohol_report/msbgsruprofiles.pdf webcite
• [2]Patten SB: Accumulation of major depressive episodes over time in a prospective study indicates that retrospectively assessed lifetime prevalence estimates are too low. BMC Psychiatry 2009, 9:19.
• [3]Sullivan LE, Fiellin DA, O’Connor PG: The prevalence and impact of alcohol problems in major depression: a systematic review. Am J Med 2005, 118:330-341.
• [4]Wollin SD, Jones PJ: Alcohol, red wine and cardiovascular disease. J Nutr 2001, 131:1401-1404.
• [5]Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K: Alcohol and coronary heart disease: a meta-analysis. Addiction 2000, 95:1505-1523.
• [6]Cahill PA, Redmond EM: Alcohol and cardiovascular disease-modulation of vascular cell function. Nutrients 2012, 4:297-318.
• [7]Belmaker RH, Agam G: Major depressive disorder. N Engl J Med 2008, 358:55-68.
• [8]Poole L, Dickens C, Steptoe A: The puzzle of depression and acute coronary syndrome: reviewing the role of acute inflammation. J Psychosom Res 2011, 71:61-68.
• [9]Gea A, Martinez-Gonzalez MA, Toledo E, Sanchez-Villegas A, Bes-Rastrollo M, Nuñez-Cordoba JM, Sayon-Orea C, Beunza JJ: A longitudinal assessment of alcohol intake and incident depression: the SUN Project. BMC Public Health 2012, 12:954.
• [10]Perreira KM, Sloan FA: Excess alcohol consumption and health outcomes: a 6-year follow-up of men over age 50 from the health and retirement study. Addiction 2002, 97:301-310.
• [11]Mackie CJ, Castellanos-Ryan N, Conrod PJ: Personality moderates the longitudinal relationship between psychological symptoms and alcohol use in adolescents. Alcohol Clin Exp Res 2011, 35:703-716.
• [12]Bulloch A, Lavorato D, Williams J, Patten S: Alcohol consumption and major depression in the general population: the critical importance of dependence. Depress Anxiety 2012, 29:1058-1064.
• [13]Wang J, Patten SB: Alcohol consumption and major depression: findings from a follow-up study. Can J Psychiatry 2001, 46:632-638.
• [14]Clark DB, De Bellis MD, Lynch KG, Cornelius JR, Martin CS: Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes. Drug Alcohol Depend 2003, 69:51-60.
• [15]Repetto PB, Zimmerman MA, Caldwell CH: A longitudinal study of the relationship between depressive symptoms and alcohol use in a sample of inner-city black youth. J Stud Alcohol 2004, 65:169-178.
• [16]Mason WA, Kosterman R, Haggerty KP, Hawkins JD, Redmond C, Spoth RL, Shin C: Dimensions of adolescent alcohol involvement as predictors of young-adult major depression. J Stud Alcohol Drugs 2008, 69:275-285.
• [17]Brook DW, Brook JS, Zhang C, Cohen P, Whiteman M: Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders. Arch Gen Psychiatry 2002, 59:1039-1044.
• [18]Sexton H, Lipton RI, Nilssen O: Relating alcohol use and mood: results from the Tromsø study. J Stud Alcohol 1999, 60:111-119.
• [19]Paljärvi T, Koskenvuo M, Poikolainen K, Kauhanen J, Sillanmäki L, Mäkelä P: Binge drinking and depressive symptoms: a 5-year population-based cohort study. Addiction 2009, 104:1168-1178.
• [20]Tait RJ, French DJ, Burns R, Anstey KJ: Alcohol use and depression from middle age to the oldest old: gender is more important than age. Int Psychogeriatr 2012, 24:1275-1283.
• [21]Ewing JA: Detecting alcoholism. The CAGE questionnaire. JAMA 1984, 252:1905-1907.
• [22]Martínez-González MÁ, Corella D, Salas-Salvadó J, Ros E, Covas MI, Fiol M, Wärnberg J, Arós F, Ruíz-Gutiérrez V, Lamuela-Raventós RM, Lapetra J, Muñoz MÁ, Martínez JA, Sáez G, Serra-Majem L, Pintó X, Mitjavila MT, Tur JA, Portillo MP, Estruch R, PREDIMED Study Investigators: Cohort profile: design and methods of the PREDIMED study. Int J Epidemiol 2012, 41:377-385.
• [23]Estruch R, Ros E, Salas-Salvadó J, Covas MI, Corella D, Arós F, Gómez-Gracia E, Ruiz-Gutiérrez V, Fiol M, Lapetra J, Lamuela-Raventos RM, Serra-Majem L, Pintó X, Basora J, Muñoz MA, Sorlí JV, Martínez JA, Martínez-González MA, PREDIMED Study Investigators: Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013, 368:1279-1290.
• [24]Effects of Mediterranean diet on the primary prevention of cardiovascular disease. http://www.controlled-trials.com/ISRCTN35739639 webcite
• [25]Willett W, Stampfer M: Implications of total energy intake for epidemiologic analyses. In Nutritional Epidemiology. 2nd edition. Edited by Willet W. New York: Oxford University Press; 1998:273-301.
• [26]Fernández-Ballart JD, Piñol JL, Zazpe I, Corella D, Carrasco P, Toledo E, Perez-Bauer M, Martínez-González MA, Salas-Salvadó J, Martín-Moreno JM: Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br J Nutr 2010, 103:1808-1816.
• [27]Twisk JWR: Generalized estimating equations. In Applied Longitudinal Data Analysis for Epidemiology. New York: Cambridge University Press; 2003:62-77.
• [28]Greenland S: Dose–response and trend analysis in epidemiology: alternatives to categorical analysis. Epidemiology 1995, 6:356-365.
• [29]Fergusson DM, Boden JM, Horwood LJ: Tests of causal links between alcohol abuse or dependence and major depression. Arch Gen Psychiatry 2009, 66:260-266.
• [30]Boden JM, Fergusson DM: Alcohol and depression. Addiction 2011, 106:906-914.
• [31]Sanchez-Villegas A, Martínez-González MA: Diet, a new target to prevent depression? BMC Med 2013, 11:3.
• [32]Sánchez-Villegas A, Delgado-Rodríguez M, Alonso A, Schlatter J, Lahortiga F, Serra Majem L, Martínez-González MA: Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 2009, 66:1090-1098.
• [33]Moscato BS, Russell M, Zielezny M, Bromet E, Egri G, Mudar P, Marshall JR: Gender differences in the relation between depressive symptoms and alcohol problems: a longitudinal perspective. Am J Epidemiol 1997, 146:966-974.
• [34]Schutte KK, Hearst J, Moos RH: Gender differences in the relations between depressive symptoms and drinking behavior among problem drinkers: a three-wave study. J Consult Clin Psychol 1997, 65:392-404.
• [35]Baraona E, Abittan CS, Dohmen K, Moretti M, Pozzato G, Chayes ZW, Schaefer C, Lieber CS: Gender differences in pharmacokinetics of alcohol. Alcohol Clin Exp Res 2001, 25:502-507.
• [36]Weissman MM, Bland R, Joyce PR, Newman S, Wells JE, Wittchen HU: Sex differences in rates of depression: cross-national perspectives. J Affect Disord 1993, 29:77-84.
• [37]Bastianetto S, Zheng WH, Quirion R: Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br J Pharmacol 2000, 131:711-720.
• [38]Han YS, Zheng WH, Bastianetto S, Chabot JG, Quirion R: Neuroprotective effects of resveratrol against h-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase C. Br J Pharmacol 2004, 141:997-1005.
• [39]Gao ZB, Hu GY: Trans-resveratrol, a red wine ingredient, inhibits voltage-activated potassium currents in rat hippocampal neurons. Brain Res 2005, 1056:68-75.
• [40]Gao ZB, Chen XQ, Hu GY: Inhibition of excitatory synaptic transmission by trans-resveratrol in rat hippocampus. Brain Res 2006, 1111:41-47.
• [41]Campbell S, Macqueen G: The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci 2004, 29:417-426.
• [42]Mortensen EL, Jensen HH, Sanders SA, Reinisch JM: Better psychological functioning and higher social status may largely explain the apparent health benefits of wine: a study of wine and beer drinking in young Danish adults. Arch Intern Med 2001, 161:1844-1848.
• [43]Martin-Moreno JM, Boyle P, Gorgojo L, Maisonneuve P, Fernandez-Rodriguez JC, Salvini S, Willett WC: Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 1993, 22:512-519.
• [44]de la Fuente-Arrillaga C, Ruiz ZV, Bes-Rastrollo M, Sampson L, Martinez-González MA: Reproducibility of an FFQ validated in Spain. Public Health Nutr 2010, 13:1364-1372.