Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study

BMC Psychiatry

Ling-jiang Li¹  Zhi-jun Zhang⁷  Jian-song Zhou⁴  Ze-xuan Li⁴  Jun Liu³  Hai-chen Yang⁴  Li Zhang⁴  Bao-ci Shan²  Yan Zhang⁴  Yu-ping Ning⁵  Hui-rong Zheng⁶  Hong-jun Peng⁵ 

[1] Chinese University of Hong Kong, Hong Kong, China;Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, People’s Republic of China;Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China;Mental Health Institute, The 2nd Xiangya Hospital, Central South University, No. 139 Renmin Zhong Road, Changsha, 410011, China;Guangzhou Psychiatric Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, China;Guangdong Mental Health Institute, Guangdong General Hospital, Guangzhou, China;The Department of Neuropsychiatry and Institute of Neuropsychiatric Research, Affiliated ZhongDa Hospital of Southeast University, Nanjing, China

关键词: Voxel-based analysis method;    Fractional anisotropy;    Diffusion tensor imaging;    Treatment-resistant depression;   

Others  :  1124121
DOI  :  10.1186/1471-244X-13-72

 received in 2012-08-30, accepted in 2013-02-21,  发布年份 2013

【 摘 要 】

Background

White matter abnormalities can cause network dysfunction that underlies major depressive disorder (MDD). Diffusion tensor imaging (DTI) is used to examine the neural connectivity and integrity of the white matter. Previous studies have implicated frontolimbic neural networks in the pathophysiology of MDD. Approximately 30% of MDD patients demonstrate treatment-resistant depression (TRD). However, the neurobiology of TRD remains unclear.

Methods

We used a voxel-based analysis method to analyze DTI data in young patients with TRD (n = 30; 19 males, 11 females) compared with right-handed, age- and sex-matched healthy volunteers (n = 25; 14 males, 11 females).

Results

We found a significant decrease in fractional anisotropy (FA) (corrected, cluster size >50) in the left middle frontal gyrus (peak coordinates [−18 46–14]), left limbic lobe uncus (peak coordinates [−18 2–22]), and right cerebellum posterior lobe (peak coordinates [26–34 -40]). There was no increase in FA in any brain region in patients. We also found a significant negative correlation between mean regional FA values in the three areas and Beck Depression Inventory symptom scores.

Conclusions

We found significant differences in white matter FA in the frontal lobe, limbic lobe and cerebellum between TRD patients and controls. These data suggest that abnormalities of cortical-limbic-cerebellar white matter networks may contribute to TRD in young patients.

【 授权许可】

   
2013 Peng et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 1.

Figure 3.

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