Dyspnea affective response: comparing COPD patients with healthy volunteers and laboratory model with activities of daily living

BMC Pulmonary Medicine

Robert B Banzett¹  Daniel Elkin²  Tegan Guilfoyle²  Robert W Lansing²  Richard M Schwartzstein¹  Carl R O’Donnell¹ 

[1] Harvard Medical School Boston, Boston, MA, 02115, USA;Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA

关键词: COPD;    Symptom assessment;    Dyspnea;   

Others  :  1122348
DOI  :  10.1186/1471-2466-13-27

 received in 2012-11-09, accepted in 2013-04-17,  发布年份 2013

【 摘 要 】

Background

Laboratory-induced dyspnea (breathing discomfort) in healthy subjects is widely used to study perceptual mechanisms, yet the relationship between laboratory-induced dyspnea in healthy volunteers and spontaneous dyspnea in patients with chronic lung disease is not well established. We compared affective responses to dyspnea 1) in COPD patients vs. healthy volunteers (HV) undergoing the same laboratory stimulus; 2) in COPD during laboratory dyspnea vs. during activities of daily living (ADL).

Methods

We induced moderate and high dyspnea levels in 13 COPD patients and 12 HV by increasing end-tidal CO₂ (P_ETCO₂) during restricted ventilation, evoking air hunger. We used the multidimensional dyspnea profile (MDP) to measure intensity of sensory qualities (e.g., air hunger (AH) and work/effort (W/E)) as well as immediate discomfort (A₁) and secondary emotions (A₂). Ten of the COPD subjects also completed the MDP outside the laboratory following dyspnea evoked by ADL.

Results

COPD patients and HV reported similar levels of immediate discomfort relative to sensory intensity. COPD patients and HV reported anxiety and frustration during laboratory-induced dyspnea; variation among individuals far outweighed the small differences between subject groups. COPD patients reported similar intensities of sensory qualities, discomfort, and emotions during ADL vs. during moderate laboratory dyspnea. Patients with COPD described limiting ADL to avoid greater dyspnea.

Conclusions

In this pilot study, we found no evidence that a history of COPD alters the affective response to laboratory-induced dyspnea, and no difference in affective response between dyspnea evoked by this laboratory model and dyspnea evoked by ADL.

【 授权许可】

   
2013 O’Donnell et al.; licensee BioMed Central Ltd.

【 图 表 】

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