| BMC Cardiovascular Disorders | |
| National trends in hospital length of stay for acute myocardial infarction in China | |
| Lixin Jiang5  Harlan M Krumholz3  Frank B Hu1  John A Spertus2  Qing Wang5  Lingling Li7  Sudhakar V Nuti3  Sonia Hernández-Díaz8  Xi Li5  Jing Li5  Frederick A Masoudi6  Zhenqiu Lin3  Qian Li4  | |
| [1] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA;Saint Luke’s Mid America Heart Institute, Kansas City, MO, USA;Center for Outcomes Research and Evaluation, Yale University School of Medicine, New Haven, CT, USA;Epidemiology, Worldwide Safety & Regulatory, Pfizer Inc., New York, NY, USA;National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Beilishi Road, Beijing 100037, China;Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA;Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA;Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA | |
| 关键词: Variation in care; Length of stay; Acute myocardial infarction; | |
| Others : 1103127 DOI : 10.1186/1471-2261-15-9 |
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| received in 2014-07-27, accepted in 2015-01-12, 发布年份 2015 | |
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【 摘 要 】
Background
China is experiencing increasing burden of acute myocardial infarction (AMI) in the face of limited medical resources. Hospital length of stay (LOS) is an important indicator of resource utilization.
Methods
We used data from the Retrospective AMI Study within the China Patient-centered Evaluative Assessment of Cardiac Events, a nationally representative sample of patients hospitalized for AMI during 2001, 2006, and 2011. Hospital-level variation in risk-standardized LOS (RS-LOS) for AMI, accounting for differences in case mix and year, was examined with two-level generalized linear mixed models. A generalized estimating equation model was used to evaluate hospital characteristics associated with LOS. Absolute differences in RS-LOS and 95% confidence intervals were reported.
Results
The weighted median and mean LOS were 13 and 14.6 days, respectively, in 2001 (n = 1,901), 11 and 12.6 days in 2006 (n = 3,553), and 11 and 11.9 days in 2011 (n = 7,252). There was substantial hospital level variation in RS-LOS across the 160 hospitals, ranging from 9.2 to 18.1 days. Hospitals in the Central regions had on average 1.6 days (p = 0.02) shorter RS-LOS than those in the Eastern regions. All other hospital characteristics relating to capacity for AMI treatment were not associated with LOS.
Conclusions
Despite a marked decline over the past decade, the mean LOS for AMI in China in 2011 remained long compared with international standards. Inter-hospital variation is substantial even after adjusting for case mix. Further improvement of AMI care in Chinese hospitals is critical to further shorten LOS and reduce unnecessary hospital variation.
【 授权许可】
2015 Li et al.; licensee BioMed Central.
【 预 览 】
| Files | Size | Format | View |
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| 20150201011449464.pdf | 483KB | ||
| Figure 3. | 45KB | Image | |
| Figure 2. | 44KB | Image | |
| Figure 1. | 62KB | Image |
【 图 表 】
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【 参考文献 】
- [1]Yang G, Wang Y, Zeng Y, Gao GF, Liang X, Zhou M, Wan X, Yu S, Jiang Y, Naghavi M, Vos T, Wang H, Lopez AD, Murray CJ: Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010. Lancet 2013, 381:1987-2015.
- [2]Moran A, Gu D, Zhao D, Coxson P, Wang YC, Chen CS, Liu J, Cheng J, Bibbins-Domingo K, Shen YM, He J, Goldman L: Future cardiovascular disease in china: markov model and risk factor scenario projections from the coronary heart disease policy model-china. Circ Cardiovasc Qual Outcomes 2010, 3:243-52.
- [3]Kociol RD, Lopes RD, Clare R, Thomas L, Mehta RH, Kaul P, Pieper KS, Hochman JS, Weaver WD, Armstrong PW, Granger CB, Patel MR: International variation in and factors associated with hospital readmission after myocardial infarction. JAMA 2012, 307:66-74.
- [4]Kaul P, Newby LK, Fu Y, Mark DB, Califf RM, Topol EJ, Aylward P, Granger CB, Van de Werf F, Armstrong PW: International differences in evolution of early discharge after acute myocardial infarction. Lancet 2004, 363:511-7.
- [5]Wang L, Zhang M, Guo L, Qi J, Luo H, He H, Wang X, Yang H, Wu Y, Miu C, Chen X, Wu J: Clinical pathways based on integrative medicine in chinese hospitals improve treatment outcomes for patients with acute myocardial infarction: a multicentre, nonrandomized historically controlled trial. Evid Based Complement Alternat Med 2012, 2012:821641.
- [6]Zhang Q, Zhang RY, Qiu JP, Zhang JF, Wang XL, Jiang L, Liao ML, Zhang JS, Hu J, Yang ZK, Shen WF: Prospective multicenter randomized trial comparing physician versus patient transfer for primary percutaneous coronary intervention in acute ST-segment elevation myocardial infarction. Chin Med J (Engl) 2008, 121:485-91.
- [7]Saleh SS, Callan M, Therriault M, Landor N: The cost impact of hospital-acquired conditions among critical care patients. Med Care 2010, 48:518-26.
- [8]Mark DB, Newby LK: Early hospital discharge after uncomplicated myocardial infarction: are further improvements possible? Eur Heart J 2003, 24:1613-5.
- [9]Polverejan E, Gardiner JC, Bradley CJ, Holmes-Rovner M, Rovner D: Estimating mean hospital cost as a function of length of stay and patient characteristics. Health Econ 2003, 12:935-47.
- [10]Soekhlal RR, Burgers LT, Redekop WK, Tan SS: Treatment costs of acute myocardial infarction in the Netherlands. Neth Heart J 2013, 21:230-5.
- [11]Chinese Society of Cardiology: Guidelines for the diagnosis and treatment of unstable Angina/Non–ST-Elevation Myocardial Infarction. Chin J Cardiol 2007, 35(4):295-304.
- [12]Chinese Society of Cardiology: Guidelines for the diagnosis and treatment of st segment elevation myocardial infarction. Chin J Cardiol 2010, 38(8):675-90.
- [13]Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, Ohman M, Petrie MC, Sonntag F, Uva MS, Storey RF, Wijns W, Zahger D, ESC Committee for Practice Guidelines: ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011, 32:2999-3054.
- [14]Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, Filippatos G, Fox K, Huber K, Kastrati A, Rosengren A, Steg PG, Tubaro M, Verheugt F, Weidinger F, Weis M, ESC Committee for Practice Guidelines (CPG): Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008, 29:2909-45.
- [15]O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX, Anderson JL, Jacobs AK, Halperin JL, Albert NM, Brindis RG, Creager MA, DeMets D, American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, et al.: 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2013, 127(4):e362-425.
- [16]Jneid H, Anderson JL, Wright RS, Adams CD, Bridges CR, Casey DE Jr, Ettinger SM, Fesmire FM, Ganiats TG, Lincoff AM, Peterson ED, Philippides GJ, Theroux P, Wenger NK, Zidar JP, Anderson JL, 2012 Writing Committee Members: 2012 ACCF/AHA Focused Update of the Guideline for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction (Updating the 2007 Guideline and Replacing the 2011 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2012, 126:875-910.
- [17]Berger AK, Duval S, Jacobs DR Jr, Barber C, Vazquez G, Lee S, Luepker RV: Relation of length of hospital stay in acute myocardial infarction to postdischarge mortality. Am J Cardiol 2008, 101:428-34.
- [18]Baker DW, Einstadter D, Husak SS, Cebul RD: Trends in postdischarge mortality and readmissions: has length of stay declined too far? Arch Intern Med 2004, 164:538-44.
- [19]Saczynski JS, Lessard D, Spencer FA, Gurwitz JH, Gore JM, Yarzebski J, Goldberg RJ: Declining length of stay for patients hospitalized with AMI: impact on mortality and readmissions. Am J Med 2010, 123:1007-15.
- [20]Kaboli PJ, Go JT, Hockenberry J, Glasgow JM, Johnson SR, Rosenthal GE, Jones MP, Vaughan-Sarrazin M: Associations between reduced hospital length of stay and 30-day readmission rate and mortality: 14-year experience in 129 Veterans Affairs hospitals. Ann Intern Med 2012, 157:837-45.
- [21]Kotowycz MA, Cosman TL, Tartaglia C, Afzal R, Syal RP, Natarajan MK: Safety and feasibility of early hospital discharge in ST-segment elevation myocardial infarction--a prospective and randomized trial in low-risk primary percutaneous coronary intervention patients (the Safe-Depart Trial). Am Heart J 2010, 159:117 e1-6.
- [22]Yip HK, Wu CJ, Chang HW, Hang CL, Wang CP, Yang CH, Hung WC, Yu TH, Yeh KH, Chua S, Fu M, Chen MC: The feasibility and safety of early discharge for low risk patients with acute myocardial infarction after successful direct percutaneous coronary intervention. Jpn Heart J 2003, 44:41-9.
- [23]Smith EJ, Rothman MT, Timmis AD: Prolonged hospital stay after acute myocardial infarction: assessing the evidence. Lancet 2004, 363:502-3.
- [24]Topol EJ, Burek K, O'Neill WW, Kewman DG, Kander NH, Shea MJ, Schork MA, Kirscht J, Juni JE, Pitt B: A randomized controlled trial of hospital discharge three days after myocardial infarction in the era of reperfusion. N Engl J Med 1988, 318:1083-8.
- [25]Dharmarajan K, Li J, Li X, Lin Z, Krumholz HM, Jiang L: The China Patient-Centered Evaluative Assessment of Cardiac Events (China PEACE) retrospective study of acute myocardial infarction: study design. Circ Cardiovasc Qual Outcomes 2013, 6:732-40.
- [26]Li J, Li X, Wang Q, Hu S, Wang Y, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, for the China PEACE Collaborative Group: Trends in characteristics, treatment, and outcomes among patients with ST-segment elevation myocardial infarction in China from 2001 to 2011: China PEACE-Retrospective AMI study. Lancet 2014. doi:10.1016/S0140-6736(14)60921-1
- [27]Khouw N, Wasim M, Aziz A, Uppal H, Chandran S, Potluri R: Length of hospital stay is shorter in South Asian patients with myocardial infarction. Int J Cardiol 2014, 171:e54-5.
- [28]Choi JS, Kim YA, Kang YU, Kim CS, Bae EH, Ma SK, Ahn YK, Jeong MH, Kim SW: Clinical impact of hospital-acquired anemia in association with acute kidney injury and chronic kidney disease in patients with acute myocardial infarction. PLoS One 2013, 8:e75583.
- [29]Hamada H, Sekimoto M, Imanaka Y: Effects of the per diem prospective payment system with DRG-like grouping system (DPC/PDPS) on resource usage and healthcare quality in Japan. Health Policy 2012, 107:194-201.
- [30]Jones K, Saxon L, Cunningham W, Adams P: Secondary prevention for patients after a myocardial infarction: summary of updated NICE guidance. BMJ 2013, 347:f6544.
- [31]Ades PA: Cardiac rehabilitation and secondary prevention of coronary heart disease. N Engl J Med 2001, 345(12):892-902.
- [32]Wang W, Chair SY, Thompson DR, Twinn SF: Health care professionals' perceptions of hospital-based cardiac rehabilitation in mainland China: an exploratory study. J Clin Nurs 2009, 18(24):3401-8.
- [33]Liu CY, Wang XY, Hua J: Which future for doctors in China? Lancet 2013, 382:937.
- [34]Ending violence against doctors in China Lancet 2012, 379:1764.
- [35]Yin J, Luras H, Hagen TP, Dahl FA: The effect of activity-based financing on hospital length of stay for elderly patients suffering from heart diseases in Norway. BMC Health Serv Res 2013, 13:172. BioMed Central Full Text
- [36]Gao C, Xu F, Liu GG: Payment reform and changes in health care in China. Soc Sci Med 2014, 111:10-6.
- [37]Implementation details on the basic medical insurance for urban Residents in Beijing [ http://www.bjld.gov.cn/cardbiz/BulletinChild/122/201151673430/news.htm webcite]
- [38]Pilot schemes on the basic medical insurance for Urban Residents in Shanghai http://www.shanghai.gov.cn/shanghai/node2314/node3124/node3125/node3131/userobject6ai1841.html webcite
- [39]Santolucito PA, Tighe DA, McManus DD, Yarzebski J, Lessard D, Gore JM, Goldberg RJ: Management and outcomes of renal disease and acute myocardial infarction. Am J Med 2010, 123:847-55.
- [40]Kuo YF, Goodwin JS: Effect of hospitalists on length of stay in the medicare population: variation according to hospital and patient characteristics. J Am Geriatr Soc 2010, 58:1649-57.
- [41]Chinese Ministry of Health: Clinical pathway management guidelines (trial basis). http://www.nhfpc.gov.cn/yzygj/s3589/200910/479af260b55a4fc3b4b978321b56b465.shtml webcite
- [42]Drye EE, Normand SL, Wang Y, Ross JS, Schreiner GC, Han L, Rapp M, Krumholz HM: Comparison of hospital risk-standardized mortality rates calculated by using in-hospital and 30-day models: an observational study with implications for hospital profiling. Ann Intern Med 2012, 156:19-26.
- [43]Hakkinen U, Chiarello P, Cots F, Peltola M, Ratto H: Patient classification and hospital costs of care for acute myocardial infarction in nine European countries. Health Econ 2012, 21(Suppl 2):19-29.
- [44]Vavalle JP, Lopes RD, Chen AY, Newby LK, Wang TY, Shah BR, Ho PM, Wiviott SD, Peterson ED, Roe MT, Granger CB: Hospital length of stay in patients with non-ST-segment elevation myocardial infarction. Am J Med 2012, 125:1085-94.
- [45]Chen E, Naylor CD: Variation in hospital length of stay for acute myocardial infarction in Ontario, Canada. Med Care 1994, 32:420-35.
- [46]Pearson SD, Kleefield SF, Soukop JR, Cook EF, Lee TH: Critical pathways intervention to reduce length of hospital stay. Am J Med 2001, 110:175-80.
- [47]Huerta S, Heber D, Sawicki MP, Liu CD, Arthur D, Alexander P, Yip I, Li ZP, Livingston EH: Reduced length of stay by implementation of a clinical pathway for bariatric surgery in an academic health care center. Am Surg 2001, 67:1128-35.
- [48]Stephen AE, Berger DL: Shortened length of stay and hospital cost reduction with implementation of an accelerated clinical care pathway after elective colon resection. Surgery 2003, 133:277-82.
- [49]Powell-Jackson T, Yip WC, Han W: Realigning demand and supply side incentives to improve primary health care seeking in rural China. Health Econ 2014. doi:10.1002/hec.3060
- [50]Reinhold T, Thierfelder K, Muller-Riemenschneider F, Willich SN: Health economic effects after DRG-implementation–a systematic overview. Gesundheitswesen 2009, 71(5):306-12.
- [51]Kominski GF, Witsberger C: Trends in length of stay for Medicare patients: 1979–87. Health Care Financ Rev 1993, 15(2):121-35.
- [52]Wang Z, Liu R, Li P, Jiang C: Exploring the transition to DRGs in developing countries: a case study in Shanghai, China. Pak J Med Sci 2014, 30(2):250-5.
- [53]Spencer FA, Lessard D, Gore JM, Yarzebski J, Goldberg RJ: Declining length of hospital stay for acute myocardial infarction and postdischarge outcomes: a community-wide perspective. Arch Intern Med 2004, 164:733-40.
- [54]Paul SD, Eagle KA, Guidry U, DiSalvo TG, Villarreal-Levy G, Smith AJ, O'Donnell CJ, Mahjoub ZA, Muluk V, Newell JB, O’Gara PT: Do gender-based differences in presentation and management influence predictors of hospitalization costs and length of stay after an acute myocardial infarction? Am J Cardiol 1995, 76:1122-5.
- [55]Schellings DA, Ottervanger JP, Hof AW V 't, de Boer MJ, Dambrink JH, Hoorntje JC, Gosselink And M, Suryapranata H, Zwolle Myocardial Infarction Study Group: Predictors and importance of prolonged hospital stay after primary PCI for ST elevation myocardial infarction. Coron Artery Dis 2011, 22:458-62.
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