Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial

BMC Pulmonary Medicine

Jennifer A Alison¹  Peter T P Bye⁵  Peter Corte³  Phillip A Munoz³  Zoe J McKeough⁴  Marita T Dale² 

[1] Department of Physiotherapy, Royal Prince Alfred Hospital, Sydney, NSW, Australia;Physiotherapy Department, St Vincent’s Hospital, Sydney, NSW, Australia;Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia;Clinical and Rehabilitation Sciences, Faculty of Health Sciences, The University of Sydney, Sydney, NSW, Australia;Sydney Medical School, The University of Sydney, Sydney, NSW, Australia

关键词: Health-related quality of life;    Physical activity;    Pulmonary rehabilitation;    Exercise;    Interstitial lung disease;    Diffuse pleural thickening;    Asbestosis;   

Others  :  1091332
DOI  :  10.1186/1471-2466-14-180

 received in 2014-06-29, accepted in 2014-10-17,  发布年份 2014

【 摘 要 】

Background

The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.

Methods

Participants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George’s Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.

Results

Thirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).

Conclusion

Exercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.

Clinical trial registration number

ANZCTR12608000147381. Date trial registered: 27.03.2008.

【 授权许可】

   
2014 Dale et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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