Oseltamivir use and outcomes during the 2009 influenza A H1N1 pandemic in Taiwan

BMC Public Health

Mei-Shu Lai¹  Chia-Hsuin Chang²  Jen-Hsiang Chuang⁴  Chia-Ping Su⁴  Jiun-Ling Wang⁵  Chia-Hung Liu³ 

[1] Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan;Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;Department of Family Medicine, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan;Taiwan Centers for Disease Control, Taipei, Taiwan;Department of Internal Medicine, E-Da hospital/ I-Shou University, Kaohsiung, Taiwan

关键词: Mortality;    Pandemic;    H1N1 subtype;    Influenza A virus;    Oseltamivir;   

Others  :  1162036
DOI  :  10.1186/1471-2458-13-646

 received in 2013-01-16, accepted in 2013-07-05,  发布年份 2013

【 摘 要 】

Background

The Taiwan CDC provided free oseltamivir to all patients with influenza infections confirmed by rapid testing or who had clinical warning symptoms during the 2009 H1N1 influenza pandemic in Taiwan. However, oseltamivir utilization patterns, cost, and outcomes among oseltamivir-treated patients remained unclear.

Method

A population-level, observational cohort study was conducted using the Taiwan National Health Insurance Database from January to December 2009 to describe the use of oseltamivir.

Result

Prescription trend over weeks increased after a change in government policy and responded to the influenza virus activity. The overall prescription rate was 22.33 per 1000 persons, with the highest prescription rate of 116.5 for those aged 7–12 years, followed by 69.0 for those aged 13–18 years, while the lowest rate was 1.7 for those aged ≥ 65 years. As influenza virus activity increased, the number of prescriptions for those aged ≤18 years rose significantly, whereas no substantial change was observed for those aged ≥65 years. There were also regional variations in terms of oseltamivir utilization and influenza complication rates.

Conclusions

Oseltamivir was widely used in the 2009 H1N1 influenza pandemic in Taiwan, particularly in those aged 7–18 years. The number of prescriptions for oseltamivir increased with a change in government policy and with increasing cases of pandemic influenza. Further study is needed to examine whether there is an over- or under-use of anti-influenza drugs in different age groups or regions and to examine the current policy of public use of anti-influenza drugs to reduce influenza-associated morbidity and mortality.

【 授权许可】

   
2013 Liu et al.; licensee BioMed Central Ltd.

【 图 表 】

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