Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

BMC Gastroenterology

Yati Soenarto¹  Soetjiningsih Budiarsa²  I Gusti Ngurah Sanjaya-Putra³  I Putu Gede Karyana³  Hendra Salim³ 

[1] Division of Gastroenterology and Hepatology, Department of Child Health, Medical School, Gadjah Mada University/Sardjito Hospital, Yogyakarta, Indonesia;Division of Child Growth and Development – Social Pediatrics, Department of Child Health, Medical School, Udayana University/Sanglah Hospital, Denpasar, Indonesia;Division of Gastroenterology and Hepatology, Department of Child Health, Medical School, Udayana University/Sanglah Hospital, Denpasar, Indonesia

关键词: Children;    Rotavirus;    Acute diarrhea;   

Others  :  855656
DOI  :  10.1186/1471-230X-14-54

 received in 2013-12-24, accepted in 2014-03-19,  发布年份 2014

【 摘 要 】

Background

Diarrhea is a major public health concern throughout the world because the prevalence of morbidity of diarrhea has not changed significantly in the past decade. It remains the third leading cause of death among children less than 5 years of age. Recent surveillance studies have shown that rotavirus is a significant cause of pediatric hospitalization and death due to diarrhea. Indonesia has limited data on risk factors, disease burden, and deaths in children due to rotavirus diarrhea. The objective of this study was to examine the above mentioned factors related to rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar.

Methods

A prospective cohort study was conducted at Sanglah Hospital Denpasar from April 2009 to December 2011. The present study was part of a nationwide study on Extension for Hospital-based Surveillance and Strain Characterization of Rotavirus Diarrhea Indonesia involving four hospitals throughout Indonesia as a part of the Asian Rotavirus Surveillance Network. We studied children aged <5 years who were hospitalized with acute diarrhea, and analyzed their stool samples using an immunoassay that detects the rotavirus antigen.

Results

A total of 656 patients met the inclusion criteria for this study. Of 5805 patients under the age of 5 who were hospitalized between April 2009 and December 2011, the prevalence of diarrhea among hospitalized pediatric patients was 11.3% and the prevalence of rotavirus diarrhea was 49.8%. The male to female ratio of those affected by rotavirus was 1.6:1. The occurrence of vomiting was significantly higher in rotavirus diarrhea than in non-rotavirus diarrhea (RR, 1.4; 95% CI, 1.08 to 1.70; p = 0.004).

Conclusions

Diarrhea remains an important cause of hospitalization in children, and rotavirus was the most important etiology. We found that boys had a greatest risk of rotavirus infection than girls. Good nutritional status and breastfeeding provided the same protection against rotavirus and non-rotavirus diarrhea.

【 授权许可】

   
2014 Salim et al.; licensee BioMed Central Ltd.

【 图 表 】

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