Autonomic nervous system and hypothalamic–pituitary–adrenal axis response to experimentally induced cold pain in adolescent non-suicidal self-injury – study protocol

BMC Psychiatry

Michael Kaess²  Marco Warth¹  Lena Rinnewitz²  Julian Koenig³ 

[1] School of Therapeutic Sciences, SRH University Heidelberg, Heidelberg, Germany;Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany;Department of Psychology, The Ohio State University, Columbus, OH, USA

关键词: Hypothalamic–pituitary–adrenal axis;    Autonomic nervous system;    Pain sensitivity;    Non-suicidal self-injury;   

Others  :  1217894
DOI  :  10.1186/s12888-015-0544-4

 received in 2015-01-11, accepted in 2015-06-25,  发布年份 2015

【 摘 要 】

Background

Adolescent non-suicidal self-injury (NSSI) is associated with altered sensitivity to experimentally induced pain. Adolescents engaging in NSSI report greater pain threshold and pain tolerance, as well as lower pain intensity and pain unpleasantness compared to healthy controls. The experience of pain is associated with reactivity of both the autonomic nervous system (ANS) and the hypothalamic–pituitary–adrenal (HPA) axis. However, previous research has not yet systematically addressed differences in the physiological response to experimentally induced pain comparing adolescents with NSSI and age- and sex-matched healthy controls.

Methods/Design

Adolescents with NSSI and healthy controls undergo repeated painful stimulation with the cold pressor task. ANS activity is continuously recorded throughout the procedure to assess changes in heart rate and heart rate variability. Blood pressure is monitored and saliva is collected prior to and after nociceptive stimulation to assess levels of saliva cortisol.

Discussion

The study will provide evidence whether lower pain sensitivity in adolescents with NSSI is associated with blunted physiological and endocrinological responses to experimentally induced pain compared to healthy controls. Extending on the existing evidence on altered pain sensitivity in NSSI, measured by self-reports and behavioural assessments, this is the first study to take a systematic approach in evaluating the physiological response to experimentally induced pain in adolescent NSSI.

Trial Registration

Deutsche Register Klinischer Studien, Study ID: DRKS00007807; Trial Registration Date: 13.02.2015

【 授权许可】

   
2015 Koenig et al.

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