BMC Pulmonary Medicine | |
A controlled study of community-based exercise training in patients with moderate COPD | |
Christopher B Cooper2  Chi-Hong Tseng1  Thomas W Storer2  Molly Quinn2  Marlon Abrazado2  Shefalee Amin2  | |
[1] Department of Biomathematics, David Geffen School of Medicine at UCLA, AV-327 Center of Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095-1690, USA;Exercise Physiology Research Laboratory, Departments of Physiology and Medicine, David Geffen School of Medicine at University of California, Los Angeles, 37-131 Center for Health Sciences, 10833 Le Conte Avenue, Los Angeles, CA 90095-1690, USA | |
关键词: Exercise rehabilitation moderate COPD; Community; | |
Others : 1109570 DOI : 10.1186/1471-2466-14-125 |
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received in 2014-03-10, accepted in 2014-06-12, 发布年份 2014 | |
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【 摘 要 】
Background
The effectiveness of clinic-based pulmonary rehabilitation in advanced COPD is well established, but few data exist for less severe patients treated in alternative settings. The purpose of this study was to investigate whether a novel, community-based exercise program (CBE) was feasible and effective for patients with moderate COPD.
Methods
Nineteen patients with moderate COPD (mean FEV1 62%) and self-reported exercise impairment were randomized to 12-weeks of progressive endurance and strength training at a local health club under the guidance of a certified personal trainer, or to continuation of unsupervised habitual physical activity. Outcomes assessed at baseline and 12 weeks included session compliance, intensity adherence, treadmill endurance time, muscle strength, dyspnea, and health status.
Results
Compliance was 94% and adherence was 83%. Comparisons between CBE and control groups yielded the following mean (SEM) differences in favor of CBE: endurance time 134 (74) seconds versus -59 (49) seconds (P = 0.041) and TDI 5.1 (0.8) versus -0.2 (0.5) (P < 0.001). The CBE group increased muscle strength (weight lifted) by 11.8 kilograms per subject per week of training (P < 0.001). SGRQ was not significantly changed.
Conclusions
We demonstrated the feasibility and effectiveness of a novel community-based exercise program involving health clubs and personal trainers for patients with moderate COPD.
Trial registration
ClinicalTrials.gov Identifier NCT01985529.
【 授权许可】
2014 Amin et al.; licensee BioMed Central Ltd.
【 预 览 】
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【 参考文献 】
- [1]Cooper CB: The connection between chronic obstructive pulmonary disease symptoms and hyperinflation and its impact on exercise and function. Am J Med 2006, 119:21-31.
- [2]Schols AM, Soeters PB, Dingemans AM, Mostert R, Frantzen PJ, Wouters EF: Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis 1993, 147:1151-1156.
- [3]Schols AM, Slangen J, Volovics L, Wouters EF: Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 157:1791-1797.
- [4]Casaburi R: Skeletal muscle dysfunction in chronic obstructive pulmonary disease. Med Sci Sports Exerc 2001, 33:S662-S670.
- [5]Jakobsson P, Jorfeldt L, Henriksson J: Metabolic enzyme activity in the quadriceps femoris muscle in patients with severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995, 151:374-377.
- [6]Maltais F, Simard AA, Simard C, Jobin J, Desgagnes P, LeBlanc P: Oxidative capacity of the skeletal muscle and lactic acid kinetics during exercise in normal subjects and in patients with COPD. Am J Respir Crit Care Med 1996, 153:288-293.
- [7]Bernard S, LeBlanc P, Whittom F, Carrier G, Jobin J, Belleau R, Maltais F: Peripheral muscle weakness in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 158:629-634.
- [8]Gosselink R, Troosters T, Decramer M: Peripheral muscle weakness contributes to exercise limitation in COPD. Am J Respir Crit Care Med 1996, 153:976-980.
- [9]Celli BR, MacNee W: Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J 2004, 23:932-946.
- [10]Griffiths TL, Burr ML, Campbell IA, Lewis-Jenkins V, Mullins J, Shiels K, Turner-Lawlor PJ, Payne N, Newcombe RG, Ionescu AA, Thomas J, Turnbridge J: Results at 1 year of outpatient multidisciplinary pulmonary rehabilitation: a randomised controlled trial. Lancet 2000, 355:362-368.
- [11]Lacasse Y, Wong E, Guyatt GH, King D, Cook DJ, Goldstein RS: Meta-analysis of respiratory rehabilitation in chronic obstructive pulmonary disease. Lancet 1996, 348:1115-1119.
- [12]Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell DE, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T: American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med 2006, 173:1390-1413.
- [13]Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001, 163:1256-1276.
- [14]Pitta F, Troosters T, Spruit MA, Probst VS, Decramer M, Gosselink R: Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005, 171:972-977.
- [15]Ries AL, Bauldoff GS, Carlin BW, Casaburi R, Emery CF, Mahler DA, Make B, Rochester CL, Zuwallack R, Herrerias C: Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest 2007, 131:4S-42S.
- [16]Bickford LS, Hodgkin JE, McInturff SL: National pulmonary rehabilitation survey. Update. J Cardiopulm Rehabil 1995, 15:406-411.
- [17]Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R: Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013, 187(4):347-365.
- [18]Cooper CB, Abrazado M, Legg D, Kesten S: Development and implementation of treadmill exercise testing protocols in COPD. Int J Chron Obstruct Pulmon Dis 2010, 5:375-385.
- [19]Mahler DA, Weinberg DH, Wells CK, Feinstein AR: The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984, 85:751-758.
- [20]Jones PW, Quirk FH, Baveystock CM, Littlejohns P: A self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis 1992, 145:1321-1327.
- [21]Cade J, Thompson R, Burley V, Warm D: Development, validation and utilisation of food-frequency questionnaires - a review. Public Health Nutr 2002, 5:567-587.
- [22]Anthonisen NR, Manfreda J, Warren CP, Hershfield ES, Harding GK, Nelson NA: Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987, 106:196-204.
- [23]O'Donnell DE, Fluge T, Gerken F, Hamilton A, Webb K, Aguilaniu B, Make B, Magnussen H: Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J 2004, 23:832-840.
- [24]O'Donnell DE, Lam M, Webb KA: Measurement of symptoms, lung hyperinflation, and endurance during exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998, 158:1557-1565.
- [25]O'Donnell DE, Voduc N, Fitzpatrick M, Webb KA: Effect of salmeterol on the ventilatory response to exercise in chronic obstructive pulmonary disease. Eur Respir J 2004, 24:86-94.
- [26]Maltais F, Hamilton A, Marciniuk D, Hernandez P, Sciurba FC, Richter K, Kesten S, O'Donnell DE: Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD. Chest 2005, 128:1168-1178.
- [27]O'Donnell DE, Casaburi R, Vincken W, Puente-Maestu L, Swales J, Lawrence D, Kramer B, Inable study group: Effect of indacaterol on exercise endurance and lung hyperinflation in COPD. Respir Med 2011, 105:297-309. 1030-6
- [28]Fischer MJ, Scharloo M, Abbink JJ, van’t Hul AJ, van Ranst D, Rudolphus A, Weinman J, Rabe KF, Kaptein AA: Drop-out and attendance in pulmonary rehabilitation: the role of clinical and psychosocial variables. Respir Med 2009, 103:1564-1571.
- [29]Effing T, Zielhuis G, Kerstjens H, van der Valk P, van der Palen J: Community based physiotherapeutic exercise in COPD self-management: a randomised controlled trial. Respir Med 2011, 105:418-426.
- [30]Man WD, Polkey MI, Donaldson N, Gray BJ, Moxham J: Community pulmonary rehabilitation after hospitalisation for acute exacerbations of chronic obstructive pulmonary disease: randomised controlled study. BMJ 2004, 329:1209.
- [31]Strijbos JH, Postma DS, van Altena R, Gimeno F, Koeter GH: A comparison between an outpatient hospital-based pulmonary rehabilitation program and a home-care pulmonary rehabilitation program in patients with COPD. A follow-up of 18 months. Chest 1996, 109:366-372.
- [32]Maltais F, Bourbeau J, Shapiro S, Lacasse Y, Perrault H, Baltzan M, Hernandez P, Rouleau M, Julien M, Parenteau S, Paradis B, Levy RD, Camp P, Lecours R, Audet R, Hutton B, Penrod JR, Picard D, Bernard S, Chronic Obstructive Pulmonary Disease Axis of Respiratory Health Network, Fonds de recherche en sante du Quebec: Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med 2008, 149:869-878.
- [33]Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop summary, updated 2007 Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2007. Accessed Jan 8 2008, at http://www.goldcopd.com webcite
- [34]Cambach W, Chadwick-Straver RV, Wagenaar RC, van Keimpema AR, Kemper HC: The effects of a community-based pulmonary rehabilitation programme on exercise tolerance and quality of life: a randomized controlled trial. Eur Respir J 1997, 10:104-113.
- [35]van Wetering CR, Hoogendoorn M, Mol SJ, Rutten-van Molken MP, Schols AM: Short- and long-term efficacy of a community-based COPD management programme in less advanced COPD: a randomised controlled trial. Thorax 2010, 65:7-13.