Clinical symptoms and performance on the continuous performance test in children with attention deficit hyperactivity disorder between subtypes: a natural follow-up study for 6 months

BMC Psychiatry

Chih-Ken Chen¹  Zong-Yi Shang²  Chen-Cheng Hsiao⁴  Yuan-Lin Chiang⁴  Yu-Shu Huang³  Liang-Jen Wang⁵ 

[1] Division of Mental Health & Drug Abuse Research, National Health Research Institutes, Miaoli, Taiwan;Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan;Department of Psychiatry, Chang Gung Memorial Hospital at Linko, Taoyuan, Taiwan;Chang Gung University School of Medicine, Taoyuan, Taiwan;Master of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan

关键词: clinical symptoms;    Continuous Performance Test;    aggressive;    subtype;    ADHD;   

Others  :  1124571
DOI  :  10.1186/1471-244X-11-65

 received in 2010-07-07, accepted in 2011-04-19,  发布年份 2011

【 摘 要 】

Background

The aims of this study were to determine the time course of improvements in attention deficit hyperactivity disorder (ADHD) clinical symptoms and neurocognitive function in a realistic clinical setting, and the differences in ADHD symptom improvement using different classifications of ADHD subtypes.

Methods

The Child Behavior Checklist (CBCL) was completed by parents of ADHD children at the initial visit. The computerized Continuous Performance Test (CPT), Swanson, Nolan, and Pelham, and Version IV Scale for ADHD (SNAP-IV), and ADHD Rating Scale (ADHD-RS) were performed at baseline, one month, three months, and six months later, respectively. Patient care including drug therapy was performed at the discretion of the psychiatrist. The ADHD patients were divided into DSM-IV subtypes (Inattentive, Hyperactive-impulsive and Combined type), and were additionally categorized into aggressive and non-aggressive subtypes by aggression scale in CBCL for comparisons.

Results

There were 50 ADHD patients with a mean age of 7.84 ± 1.64 years; 15 of them were inattentive type, 11 were hyperactive-impulsive type, and 24 were combined type. In addition, 28 of the ADHD patients were grouped into aggressive and 22 into non-aggressive subtypes. There were significant improvements in clinical symptoms of hyperactivity and inattention, and impulsivity performance in CPT during the 6-month treatment. The clinical hyperactive symptoms were significantly different between ADHD patients sub-grouping both by DSM-IV and aggression. Non-aggressive patients had significantly greater changes in distraction and impulsivity performances in CPT from baseline to month 6 than aggressive patients.

Conclusions

We found that ADHD symptoms, which included impulsive performances in CPT and clinical inattention and hyperactivity dimensions, had improved significantly over 6 months under pragmatic treatments. The non-aggressive ADHD patients might have a higher potential for improving in CPT performance than aggressive ones. However, it warrant further investigation whether the different classifications of ADHD patients could be valid for predicting the improvements in ADHD patients' clinical symptoms and neurocognitive performance.

【 授权许可】

   
2011 Wang et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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