Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies

BMC Medicine

Michael J Goldacre¹  Gavin Giovannoni²  Giulio Disanto³  Raph Goldacre¹  Sreeram V Ramagopalan² 

[1] Unit of Health-Care Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, UK;Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK;Department of Physiology, Anatomy and Genetics and Medical Research Council Functional Genomics Unit, University of Oxford, Oxford, UK

关键词: Hospital episode statistics;    Immune disease;    Vitamin D;   

Others  :  856952
DOI  :  10.1186/1741-7015-11-171

 received in 2013-05-13, accepted in 2013-07-05,  发布年份 2013

【 摘 要 】

Background

Previous studies have suggested that there may be an association between vitamin D deficiency and the risk of developing immune-mediated diseases.

Methods

We analyzed a database of linked statistical records of hospital admissions and death registrations for the whole of England (from 1999 to 2011). Rate ratios for immune-mediated disease were determined, comparing vitamin D deficient cohorts (individuals admitted for vitamin D deficiency or markers of vitamin D deficiency) with comparison cohorts.

Results

After hospital admission for either vitamin D deficiency, osteomalacia or rickets, there were significantly elevated rates of Addison’s disease, ankylosing spondylitis, autoimmune hemolytic anemia, chronic active hepatitis, celiac disease, Crohn’s disease, diabetes mellitus, pemphigoid, pernicious anemia, primary biliary cirrhosis, rheumatoid arthritis, Sjogren’s syndrome, systemic lupus erythematosus, thyrotoxicosis, and significantly reduced risks for asthma and myxoedema.

Conclusions

This study shows that patients with vitamin D deficiency may have an increased risk of developing some immune-mediated diseases, although we cannot rule out reverse causality or confounding. Further study of these associations is warranted and these data may aid further public health studies.

【 授权许可】

   
2013 Ramagopalan et al.; licensee BioMed Central Ltd.

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