Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses

BMC Complementary and Alternative Medicine

Shujuan Yu²  Fuquan Chen¹  Yi Zhao¹  Hecheng Meng¹  Mingshun Chen¹ 

[1] College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou 510640, China;Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China

关键词: Antitumor activities;    Antioxidant activities;    Phenolic compounds;    Sugar beet molasses;   

Others  :  1224051
DOI  :  10.1186/s12906-015-0847-5

 received in 2015-05-19, accepted in 2015-09-02,  发布年份 2015

【 摘 要 】

Background

In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).

Methods

Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.

Results

The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13 % against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.

Conclusions

The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.

【 授权许可】

   
2015 Chen et al.

【 图 表 】

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