A genetic predisposition score for muscular endophenotypes predicts the increase in aerobic power after training: the CAREGENE study

BMC Genetics

Luc Vanhees³  Véronique Cornelissen³  Dirk Schepers³  Roselien Buys³  Gert Matthijs⁴  Robert Fagard¹  Steven Onkelinx³  Martine Thomis²  Tom Thomaes³ 

[1] Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium;Research Centre for Exercise and Health, Department of Biomedical Kinesiology, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Heverlee, Belgium;Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, Katholieke Universiteit Leuven, Tervuursevest 101, 3001 Heverlee, Belgium;Department of Human Genetics, Centre for Human Genetics of the University Hospitals, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium

关键词: aerobic power;    genetic association;    Physical capacity;    Exercise Test;    Ischemic Heart Disease;    Cardiac Rehabilitation;   

Others  :  1122599
DOI  :  10.1186/1471-2156-12-84

 received in 2011-03-15, accepted in 2011-10-03,  发布年份 2011

【 摘 要 】

Background

It is widely accepted that genetic variability might explain a large part of the observed heterogeneity in aerobic capacity and its response to training. Significant associations between polymorphisms of different genes with muscular strength, anaerobic phenotypes and body composition have been reported. Muscular endophenotypes are positively correlated with aerobic capacity, therefore, we tested the association of polymorphisms in twelve muscular related genes on aerobic capacity and its response to endurance training.

Methods

935 Coronary artery disease patients (CAD) who performed an incremental exercise test until exhaustion at baseline and after three months of training were included. Polymorphisms of the genes were detected using the invader assay. Genotype-phenotype association analyses were performed using ANCOVA. Different models for a genetic predisposition score (GPS) were constructed based on literature and own data and were related to baseline and response VO₂ scores.

Results

Carriers of the minor allele in the R23K polymorphism of the glucocorticoid receptor gene (GR) and the ciliary neurotrophic factor gene (CNTF) had a significantly higher increase in peakVO₂ after training (p < 0.05). Carriers of the minor allele (C34T) in the adenosine monophosphate deaminase (AMPD1) gene had a significantly lower relative increase (p < 0.05) in peakVO₂. GPS of data driven models were significantly associated with the increase in peakVO₂ after training.

Conclusions

In CAD patients, suggestive associations were found in the GR, CNTF and the AMPD1 gene with an improved change in aerobic capacity after three months of training. Additionally data driven models with a genetic predisposition score (GPS) showed a significant predictive value for the increase in peakVO₂.

【 授权许可】

   
2011 Thomaes et al; licensee BioMed Central Ltd.

【 图 表 】

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