Subversion of the B-cell compartment during parasitic, bacterial, and viral infections

BMC Immunology

Yolande Richard¹  Gwenoline Borhis¹ 

[1] Université Paris Descartes, Sorbonne Paris Cité, Paris 75014, France

关键词: Parasite;    Virus;    B-reg;    BAFF;    MZ B-cells;    Memory B cells;   

Others  :  1149079
DOI  :  10.1186/s12865-015-0079-y

 received in 2014-10-07, accepted in 2015-02-24,  发布年份 2015

【 摘 要 】

Recent studies on HIV infection have identified new human B-cell subsets with a potentially important impact on anti-viral immunity. Current work highlights the occurrence of similar B-cell alterations in other viral, bacterial, and parasitic infections, suggesting that common strategies have been developed by pathogens to counteract protective immunity. For this review, we have selected key examples of human infections for which B-cell alterations have been described, to highlight the similarities and differences in the immune responses to a variety of pathogens. We believe that further comparisons between these models will lead to critical progress in the understanding of B-cell mechanisms and will open new target avenues for therapeutic interventions.

【 授权许可】

   
2015 Borhis and Richard; licensee BioMed Central.

【 图 表 】

Figure 1.

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