Long-term effects of an inpatient weight-loss program in obese children and the role of genetic predisposition-rationale and design of the LOGIC-trial

BMC Pediatrics

Martin Halle³  Helmut Langhof⁴  Bernd Wolfarth²  Bernhard Haller¹  Désirée C Wilks²  Monika Siegrist²  Melanie Rank² 

[1] Institute for Medical Statistics and Epidemiology, Technische Universität München, Klinikum rechts der Isar, Munich, Germany;Department of Prevention, Rehabilitation and Sports Medicine, Technische Universität München, Klinikum rechts der Isar, Munich, Germany;Munich Heart Alliance, Munich, Germany;Rehabilitation Clinic, Klinik Schönsicht', Berchtesgaden, Germany

关键词: Fitness;    Inflammation;    Adipokines;    Follow-up;    Polymorphism;    Lifestyle intervention;   

Others  :  1170820
DOI  :  10.1186/1471-2431-12-30

 received in 2011-12-22, accepted in 2012-03-19,  发布年份 2012

【 摘 要 】

Background

The prevalence of childhood obesity has increased worldwide, which is a serious concern as obesity is associated with many negative immediate and long-term health consequences. Therefore, the treatment of overweight and obesity in children and adolescents is strongly recommended. Inpatient weight-loss programs have shown to be effective particularly regarding short-term weight-loss, whilst little is known both on the long-term effects of this treatment and the determinants of successful weight-loss and subsequent weight maintenance.

The purpose of this study is to evaluate the short, middle and long-term effects of an inpatient weight-loss program for children and adolescents and to investigate the likely determinants of weight changes, whereby the primary focus lies on the potential role of differences in polymorphisms of adiposity-relevant genes.

Methods/Design

The study involves overweight and obese children and adolescents aged 6 to 19 years, who participate in an inpatient weight-loss program for 4 to 6 weeks. It started in 2006 and it is planned to include 1,500 participants by 2013. The intervention focuses on diet, physical activity and behavior therapy. Measurements are taken at the start and the end of the intervention and comprise blood analyses (DNA, lipid and glucose metabolism, adipokines and inflammatory markers), anthropometry (body weight, height and waist circumference), blood pressure, pubertal stage, and exercise capacity. Physical activity, dietary habits, quality of life, and family background are assessed by questionnaires. Follow-up assessments are performed 6 months, 1, 2, 5 and 10 years after the intervention: Children will complete the same questionnaires at all time points and visit their general practitioner for examination of anthropometric parameters, blood pressure and assessment of pubertal stage. At the 5 and 10 year follow-ups, blood parameters and exercise capacity will be additionally measured.

Discussion

Apart from illustrating the short, middle and long-term effects of an inpatient weight-loss program, this study will contribute to a better understanding of inter-individual differences in the regulation of body weight, taking into account the role of genetic predisposition and lifestyle factors.

Trial Registration

NCT01067157.

【 授权许可】

   
2012 Rank et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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