Toll-like receptor 9 polymorphisms are associated with severity variables in a cohort of meningococcal meningitis survivors

BMC Infectious Diseases

A Marceline van Furth²  Servaas A Morré¹  Sander Ouburg⁵  Gijs TJ van Well³  Marieke S Sanders⁴ 

[1] Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research Schools CAPHRI (School for Public Health and Primary Care) and GROW (School for Oncology & Developmental Biology), Faculty of Health, Medicine & Life Sciences, University of Maastricht, Maastricht, The Netherlands;Department of Pediatric Infectious Diseases, Immunology and Rheumatology, VU University Medical Center, Amsterdam,, 1007 MB, The Netherlands;Department of Pediatrics, Maastricht University Medical Center (MUMC+), Maastricht, 6202 AZ, The Netherlands;Department in Surgery, Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands;Laboratory for Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam,, 1007 MB, The Netherlands

Others  :  1175379
DOI  :  10.1186/1471-2334-12-112

 received in 2011-10-09, accepted in 2012-03-27,  发布年份 2012

【 授权许可】

   
2012 Sanders et al.; licensee BioMed Central Ltd

【 参考文献 】

• [1]Schroder NW, Schumann RR: Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect Dis 2005, 5(3):156-164.
• [2]WHO: bacterial meningitis. Available at: http://www.who.int/nuvi/meningitis/en/. Accessed August 2010. 2010. Internet Communication
• [3]Chavez-Bueno S, McCracken GH Jr: Bacterial meningitis in children. Pediatr Clin North Am 2005, 52(3):795-810.
• [4]Emonts M, Hazelzet JA, De GR, Hermans PW: Host genetic determinants of Neisseria meningitidis infections. Lancet Infect Dis 2003, 3(9):565-577.
• [5]Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK, Rudan I: Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis 2010, 10(5):317-328.
• [6]Koomen I, Grobbee DE, Roord JJ, Donders R, Jennekens-Schinkel A, van Furth AM: Hearing loss at school age in survivors of bacterial meningitis: assessment, incidence, and prediction. Pediatrics 2003, 112(5):1049-1053.
• [7]Koomen I, Grobbee DE, Roord JJ, Jennekens-Schinkel A, van der Lei HD, Kraak MA, et al.: Prediction of academic and behavioural limitations in school-age survivors of bacterial meningitis. Acta Paediatr 2004, 93(10):1378-1385.
• [8]Koedel U: Toll-like receptors in bacterial meningitis. Curr Top Microbiol Immunol 2009, 336:15-40.
• [9]Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al.: A Toll-like receptor recognizes bacterial DNA. Nature 2000, 408(6813):740-745.
• [10]Akira S: TLR signaling. Curr Top Microbiol Immunol 2006, 311:1-16.
• [11]Jack CS, Arbour N, Manusow J, Montgrain V, Blain M, McCrea E, et al.: TLR signaling tailors innate immune responses in human microglia and astrocytes. J Immunol 2005, 175(7):4320-4330.
• [12]Sanders MS, van Well GT, Ouburg S, Lundberg PS, van Furth AM, Morre SA: Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial meningitis in children. Clin Infect Dis 2011, 52(4):475-480.
• [13]Ng MT, Van’t Hof R, Crockett JC, Hope ME, Berry S, Thomson J, et al.: Increase in NF-kappaB binding affinity of the variant C allele of the toll-like receptor 9 -1237T/C polymorphism is associated with Helicobacter pylori-induced gastric disease. Infect Immun 2010, 78(3):1345-1352.
• [14]de Jonge RCJ, Sanders MS, Terwee CB, Heymans MB, R.J.B.J Gemke RJBJ, Koomen I, et al.Independent validation of existing model enables robust prediction of hearing loss after bacterial meningitis in childhood (submitted). Pediatrics. In press 2012
• [15]Lazarus R, Klimecki WT, Raby BA, Vercelli D, Palmer LJ, Kwiatkowski DJ, et al.: Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case–control disease association studies. Genomics 2003, 81(1):85-91.
• [16]de Jonge RC, van Furth AM, Wassenaar M, Gemke RJ, Terwee CB: Predicting sequelae and death after bacterial meningitis in childhood: a systematic review of prognostic studies. BMC Infect Dis 2010, 10(1):232. BioMed Central Full Text
• [17]Des Portes V: Long-term follow-up of bacterial meningitis - sequels in children and adults: incidence, type, and assessment issues. Med Mal Infect 2009, 39(7–8):572-580.
• [18]Weisfelt M, de BD Van, Spanjaard L, Reitsma JB, De GJ: A risk score for unfavorable outcome in adults with bacterial meningitis. Ann Neurol 2008, 63(1):90-97.
• [19]Sutherland TC, Quattroni P, Exley RM, Tang CM: Transcellular passage of Neisseria meningitidis across a polarized respiratory epithelium. Infect Immun 2010, 78(9):3832-3847.
• [20]Melvin TA, Lane AP, Nguyen MT, Lin SY: Allergic rhinitis patients with recurrent acute sinusitis have increased sinonasal epithelial cell TLR9 expression. Otolaryngol Head Neck Surg 2010, 142(5):659-664.
• [21]Sjolinder H, Jonsson AB: Olfactory nerve-a novel invasion route of neisseria meningitidis to reach the meninges. PLoS One 2010, 5(11):e14034.
• [22]Sjolinder H, Mogensen TH, Kilian M, Jonsson AB, Paludan SR: Important role for Toll-like receptor 9 in host defense against meningococcal sepsis. Infect Immun 2008, 76(11):5421-5428.
• [23]Kim KS: Mechanisms of microbial traversal of the blood–brain barrier. Nat Rev Microbiol 2008, 6(8):625-634.
• [24]Iliev AI, Stringaris AK, Nau R, Neumann H: Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9). FASEB J 2004, 18(2):412-414.
• [25]Lehnardt S: Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia 2010, 58(3):253-263.
• [26]MacIntyre G, Bailey J, Haviv I, Kowalczyk A: is-rSNP: a novel technique for in silico regulatory SNP detection. Bioinformatics 2010, 26(18):i524-i530.
• [27]Carvalho A, Osorio NS, Saraiva M, Cunha C, Almeida AJ, Teixeira-Coelho M, et al.: The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation. PLoS One 2011, 6(11):e28256.
• [28]Sam-Agudu NA, Greene JA, Opoka RO, Kazura JW, Boivin MJ, Zimmerman PA, et al.: TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg 2010, 82(4):548-555.
• [29]O’Reilly T, Ostergaard C, Vaxelaire J, Zak O: Systemic inflammation alters the inflammatory response in experimental lipopolysaccharide-induced meningitis. Clin Exp Immunol 2007, 147(1):112-119.
• [30]Brandtzaeg P, Halstensen A, Kierulf P, Espevik T, Waage A: Molecular mechanisms in the compartmentalized inflammatory response presenting as meningococcal meningitis or septic shock. Microb Pathog 1992, 13(6):423-431.
• [31]Brand A: Integrative genomics, personal-genome tests and personalized healthcare: the future is being built today. Eur J Hum Genet 2009, 17(8):977-978.