Polyethylene glycol vs. sodium phosphate for bowel preparation: A treatment arm meta-analysis of randomized controlled trials

BMC Gastroenterology

Thomas F Imperiale²  George Eckert³  Ravi Juluri¹ 

[1] Indiana University Health Physicians, Indianapolis, Indiana, USA;Center of Excellence for Implementing Evidence-based Practice, Richard L. Roudebush VAMC, Indianapolis, Indiana, USA;Department of Medicine, Division of Biostatistics, Indiana University School of Medicine, Indianapolis, Indiana, USA

关键词: Sodium Phosphate;    Polyethylene Glycol;    Bowel preparation;    Colonoscopy;   

Others  :  1114577
DOI  :  10.1186/1471-230X-11-38

 received in 2010-06-04, accepted in 2011-04-14,  发布年份 2011

【 摘 要 】

Background

Results of meta-analyses of randomized trials comparing PEG and NaP are inconsistent and have not included trials comparing either or both preps to less traditional ones.

AIM: To perform a meta-analysis by treatment arm.

Methods

Using MEDLINE and EMBASE, we identified English-language trials published from 1990 to 2008 that included PEG and/or NaP, and aggregated them by treatment arm into: 4 liter (L) PEG; 2 L PEG; split-dose PEG; two 45 ml doses of NaP +/- adjunctive medication; and NaP tablets. We compared prep quality and the proportion completing the prep.

Results

Among 71 trials (patient N = 10,201), excellent prep quality was present in 34% (CI, 26-41%) for 4 L PEG alone; 39% (CI, 26-51%) for 2 L PEG; 37% (CI, 28-46%) for split-dose PEG; 42% (CI, 33-51%) for NaP solution; 44% (CI, 38-51%) for NaP with adjunctive meds; and 58% (CI, 49-67%) for NaP tablets. Patients receiving NaP were more likely to complete the prep (97% [CI, 96-98%] vs. 90% [CI, 87-92%] for 4L PEG alone); however, completion rates for 2L PEG (98%) and split dose PEG (95%) were similar to NaP.

Conclusions

NaP tablets resulted in better prep quality and higher completion rates compared to other regimens. In comparisons limited by sample size, split dose PEG was not statistically different from NaP solution for completion rate or prep quality.

【 授权许可】

   
2011 Juluri et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

Figure 3.

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