Genetic diversity of the Mycobacterium tuberculosis Complex in San Luis Potosí, México

BMC Research Notes

Rubén López-Revilla¹  José A Enciso-Moreno²  Julián Hernández-Nieto³  Francisco Ortega-Aguilar³  Leonor Enciso-Moreno²  Lina Riego-Ruiz¹  Julio Juárez-Álvarez³  Estela López-Rocha³ 

[1] División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, Camino a la Presa San José 2055, 78216 San Luis Potosí, SLP, Mexico;Unidad de Investigación Médica de Zacatecas, Instituto Mexicano del Seguro Social, Interior Alameda 45, 98000 Zacatecas, Zac, Mexico;Laboratorio Estatal de Salud Pública, Servicios de Salud del estado de San Luis Potosí, Begonias 180, 78399 San Luis Potosí, SLP, Mexico

关键词: Social determinants of tuberculosis;    Mexico;    San Luis Potosí;    Molecular epidemiology;    Spoligotypes;    Mycobacterium bovis;    Tuberculosis;   

Others  :  1142812
DOI  :  10.1186/1756-0500-6-172

 received in 2012-11-27, accepted in 2013-04-19,  发布年份 2013

【 摘 要 】

Background

Although epidemiologic and socioeconomic criteria and biomedical risk factors indicate high-priority for tuberculosis (TB) control in Mexico, molecular epidemiology studies of the disease in the country are scarce.

Methods

Complete sociodemographic and clinical data were obtained from 248 of the 432 pulmonary TB (PTB) cases confirmed from 2006 to 2010 on the population under epidemiological surveillance in the state of San Luis Potosí, México. From most PTB cases with complete data Mycobacterium tuberculosis complex (MTC) isolates were recovered and their spoligotypes, lineages and families, geographic distribution and drug resistance determined.

Results

Pulmonary tuberculosis incidence ranged from 2.4 to 33.4 (cases per 100,000 inhabitants) in the six state sanitary jurisdictions that were grouped in regions of low (jurisdictions I-II-III), intermediate (jurisdictions IV-V) and high incidence (jurisdiction VI) with 6.2, 17.3 and 33.4 rates, respectively. Most patients were poor, 50-years-median-age males and housewives. Among the 237 MTC spoligotyped isolates, 232 corresponded to M. tuberculosis (104 spoligotypes in 24 clusters) and five to M. bovis. The predominant Euro-American lineage was distributed all over the state, the East-Asian lineage (Beijing family) in the capital city, the Indo-Oceanic (Manila family) in eastern localities, and M. bovis in rural localities.

Conclusions

In San Luis Potosí TB affects mainly poor male adults and is caused by M. tuberculosis and to a minor extent by M. bovis. There is great genotypic diversity among M. tuberculosis strains, the Euro-American lineage being much more prevalent than the Indo-Oceanic and East-Asian lineages. The frequency of resistant strains is relatively low and not associated to any particular lineage.

【 授权许可】

   
2013 López-Rocha et al.; licensee BioMed Central Ltd.

【 图 表 】

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