The relationship between irritable bowel syndrome, functional dyspepsia, chronic fatigue and overactive bladder syndrome: a controlled study 6 years after acute gastrointestinal infection

BMC Gastroenterology

Guri Rortveit³  Nina Langeland¹  Geir Egil Eide²  Kurt Hanevik⁴  Knut-Arne Wensaas⁵  Robert Persson⁵ 

[1] Department of Medicine, Haukeland University Hospital, Bergen, Norway;Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway;Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;Department of Clinical Science, University of Bergen, Bergen, Norway;Research Unit for General Practice, Uni Research Health, Bergen, Norway

关键词: Comorbidity;    Fatigue syndrome, chronic;    Urinary bladder, overactive;    Dyspepsia;    Irritable bowel syndrome;    Giardia lamblia;   

Others  :  1224302
DOI  :  10.1186/s12876-015-0296-0

 received in 2015-02-18, accepted in 2015-05-28,  发布年份 2015

【 摘 要 】

Background

To investigate in a cohort with previous gastrointestinal infection and a control group the prevalence of overactive bladder syndrome (OAB), and how it was associated with three other functional disorders; irritable bowel syndrome (IBS), functional dyspepsia (FD) and chronic fatigue (CF).

Methods

Controlled historic cohort study including 724 individuals with laboratory confirmed giardiasis six years earlier, and 847 controls matched by gender and age. Prevalence and odds ratios (OR) with 95 % confidence intervals (CI) were calculated.

Results

The prevalence of OAB was 18.7 % (134/716) in the exposed group and 13.6 % (113/833) in the control group (p = 0.007). The association between OAB and IBS was strong in the control group (OR: 2.42; 95 % CI: 1.45 to 4.04), but insignificant in the Giardia exposed (OR: 1.29; 95 % CI: 0.88 to 1.88). The association between OAB and FD was weak in both groups. CF was strongly associated with OAB (OR: 2.73; 95 % CI: 1.85 to 4.02 in the exposed and OR: 2.79; 95 % CI: 1.69 to 4.62 in the controls), and this association remained when comorbid conditions were excluded.

Conclusions

Sporadic IBS was associated with increased risk of OAB, whereas post-infectious IBS was not. An apparent association between OAB and previous Giardia infection can be ascribed to comorbid functional disorders.

【 授权许可】

   
2015 Persson et al.

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