A case–control study of occupation/industry and renal cell carcinoma risk

BMC Cancer

Mark P Purdue²  Wong-Ho Chow²  Nathanial Rothman²  Barry I Graubard²  Patricia A Stewart³  Sholom Wacholder²  Stella S Munuo⁵  Julie J Ruterbusch¹  Faith G Davis⁴  Kendra Schwartz¹  Joanne S Colt²  Sara Karami² 

[1]Wayne State University, Karmanos Cancer Institute, 110 E. Warren, Detroit, MI, 48201, USA

[2]Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, MSC 7242, Bethesda, MD 20892-7242, USA

[3]Formerly of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA

[4]University of Illinois, 877 SPHPI M/C 923, 1603 W. Taylor Street, Chicago, IL, 60612, USA

[5]Formerly of Information Management Service Inc, 6110 Executive Blvd Suite #310, Rockville, MD, 20852, USA

关键词: Race;    Industry;    Occupation;    Clear cell RCC;    Renal cancer;    Kidney cancer;   

Others  :  1080264
DOI  :  10.1186/1471-2407-12-344

 received in 2012-03-06, accepted in 2012-07-09,  发布年份 2012

【 摘 要 】

Background

The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC).

Methods

Between 2002 and 2007, a population-based case–control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models.

Results

Employment in the agricultural crop production industry for five years or more was associated with RCC (OR = 3.3 [95% CI = 1.0-11.5]) and ccRCC in particular (OR = 6.3 [95% CI = 1.7-23.3], P for trend with duration of employment = 0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (OR_RCC = 2.1 [95% CI = 1.0-4.5]; OR_ccRCC = 3.1 [95% CI = 1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (OR_RCC = 2.0 [95% CI = 0.9-4.4], P for trend = 0.093; OR_ccRCC = 3.0 [95% CI = 1.2-7.4], P for trend = 0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries.

Conclusions

Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings.

【 授权许可】

   
2012 Karami et al.; licensee BioMed Central Ltd.

【 参考文献 】

• [1]McLaughlin JK, Lipworth L, Tarone RE: Epidemiologic aspects of renal cell carcinoma. Semin Oncol 2006, 33:527-533.
• [2]Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer Statistics, 2009. CA Cancer J Clin 2009, 59:225-249.
• [3]Chow WH, Devesa SS: Contemporary epidemiology of renal cell cancer. Cancer J 2008, 14:288-301.
• [4]Weikert S, Ljungberg B: Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention. World J Urol 2010, 28:247-252.
• [5]Störkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG, Darson M, Delahunt B, Iczkowski K: Classification of renal cell carcinoma: Workgroup No. 1. Union Internationale Contre le Cancer (UICC) and the American Joint Committee on Cancer (AJCC). Cancer 1997, 80:987-989.
• [6]Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML: Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 2003, 27:612-624.
• [7]Liu H, Hemminki K, Sundquist J: Renal cell carcinoma as first and second primary cancer: etiological clues from the Swedish Family-Cancer Database. J Urol 2011, 185:2045-2049.
• [8]Heck JE, Charbotel B, Moore LE, Karami S, Zaridze DG, Matveev V, Janout V, Kollárová H, Foretova L, Bencko V, Szeszenia-Dabrowska N, Lissowska J, Mates D, Ferro G, Chow WH, Rothman N, Stewart P, Brennan P, Boffetta P: Occupation and renal cell cancer in Central and Eastern Europe. Occup Environ Med 2010, 67:47-53.
• [9]Parent ME, Hua Y, Siemiatycki J: Occupational risk factors for renal cell carcinoma in Montreal. Am J Ind Med 2000, 38:609-618.
• [10]McLaughlin JK, Malker HS, Stone BJ, Weiner JA, Malker BK, Ericsson JL, Blot WJ, Fraumeni JF Jr: Occupational risks for renal cancer in Sweden. Br J Ind Med 1987, 44:119-123.
• [11]Mattioli S, Truffelli D, Baldasseroni A, Risi A, Marchesini B, Giacomini C, Bacchini P, Violante FS, Buiatti E: Occupational risk factors for renal cell cancer: a case–control study in northern Italy. J Occup Environ Med 2002, 44:1028-1036.
• [12]Zhang Y, Cantor KP, Lynch CF, Zheng T: A population-based case–control study of occupation and renal cell carcinoma risk in Iowa. J Occup Environ Med 2004, 46:235-240.
• [13]Mellemgaard A, Engholm G, McLaughlin JK, Olsen JH: Occupational risk factors for renal-cell carcinoma in Denmark. Scand J Work Environ Health 1994, 20:160-165.
• [14]Brownson RC: A case–control study of renal cell carcinoma in relation to occupation, smoking, and alcohol consumption. Arch Environ Health 1988, 43:238-241.
• [15]Asal NR, Geyer JR, Risser DR, Lee ET, Kadamani S, Cherng N: Risk factors in renal cell carcinoma. II. Medical history, occupation, multivariate analysis, and conclusions. Cancer Detect Prev 1988, 13:263-279.
• [16]Mandel JS, McLaughlin JK, Schlehofer B, Mellemgaard A, Helmert U, Lindblad P, McCredie M, Adami HO: International renal-cell cancer study. IV. Occupation. Int J Cancer 1995, 61:601-605.
• [17]Colt JS, Schwartz K, Graubard BI, Davis F, Ruterbusch J, DiGaeteno R, Purdue M, Rothman N, Wacholder S, Chow WH: Hypertension and risk of renal cell carcinoma among white and black Americans. Epidemiol 2011, 22:797-804.
• [18]US Department of Commerce: Standard Occupational Classification Manual. Office of Federal Statistical Policy and Standards, Washington, D.C.; 1980.
• [19]US Government Printing Office: Standard Industrial Classification Manual. Washington, D.C, Executive Office of the President, Office of Management and Budget; 1987.
• [20]Li Y, Graubard BI, DiGaetano R: Weighting methods for population-based case–control studies with complex sampling. J Royal Stat Soc Series C (Applied Statistics) 2011, 60:165-185.
• [21]Korn EL, Graubard BI: Analysis of Health Surveys. John Wiley & Sons, New York; 1990.
• [22]Rust KF, Rao JN: Variance estimation for complex surveys using replication techniques. Stat Methods Med Res 1996, 5:283-310.
• [23]Tellez-Plaza M, Navas-Acien A, Crainiceanu CM, Guallar E: Cadmium exposure and hypertension in the 1999–2004 National Health and Nutition Examination Survey (NHANES). Environ Health Perspect 2008, 116:51-56.
• [24]Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ: Lead exposure and cardiovascular disease—a systematic review. Environ Health Perspect 2007, 115:472-482.
• [25]Faustini A, Forastiere F, Di Betta L, Magliola EM, Perucci CA: Cohort study of mortality among farmers and agricultural workers. Med Lav 1993, 84:31-41.
• [26]Blair A, Dosemeci M, Heineman EF: Cancer and other causes of death among male and female farmers from twenty-three states. Am J Ind Med 1993, 23:729-742.
• [27]Waggoner JK, Kullman GJ, Henneberger PK, Umbach DM, Blair A, Alavanja MC, Kamel F, Lynch CF, Knott C, London SJ, Hines CJ, Thomas KW, Sandler DP, Lubin JH, Beane Freeman LE, Hoppin JA: Mortality in the agricultural health study, 1993–2007. Am J Epidemiol 2011, 173(1):71-83.
• [28]Koutros S, Alavanja MC, Lubin JH, Sandler DP, Hoppin JA, Lynch CF, Knott C, Blair A, Freeman LE: An update of cancer incidence in the Agricultural Health Study. J Occup Enviorn Med 2010, 52:1098-1105.
• [29]Blair A, Zahm SH, Pearce NE, Heineman EF, Fraumeni JF Jr: Clues to cancer etiology from studies of farmers. Scand J Work Environ Health 1992, 18:209-215.
• [30]Schreinemachers DM: Cancer mortality in four northern wheat-producing states. Environ Health Perspect 2010, 108:873-881.
• [31]Settimi L, Comba P, Bosia S, Ciapini C, Desideri E, Fedi A, Perazzo PL, Axelson O: Cancer risk among male farmers: a multi-site case–control study. Int J Occup Med Environ Health 2001, 14:339-347.
• [32]Karami S, Boffetta P, Rothman N, Hung RJ, Stewart T, Zaridze D, Navritalova M, Mates D, Janout V, Kollarova H, Bencko V, Szeszenia-Dabrowska N, Holcatova I, Mukeria A, Gromiec J, Chanock SJ, Brennan P, Chow WH, Moore LE: Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. Carcinogenesis 2008, 29:1567-1571.
• [33]McCredie M, Stewart JH: Risk factors for kidney cancer in New South Wales, IV. Occupation. Br J Ind Med 1993, 50:349-354.
• [34]Moore LE, Boffetta P, Karami S, Brennan P, Stewart PS, Hung R, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Gromiec J, Holcatova I, Merino M, Chanock S, Chow WH, Rothman N: Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res 2010, 70:6527-6536.
• [35]Charbotel B, Fevotte J, Hours M, Martin JL, Bergeret A: Case–control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects. Ann Occup Hyg 2006, 50:777-787.
• [36]Centers for Diseases Prevention and Control: Trichloroethylene.  ,  ;  .
• [37]Bakke B, Stewart PA, Waters MA: Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. J Occup Environ Hyg 2007, 4:375-390.
• [38]United States Environmental Protection Agency: Sources, emission and exposure for Trichloroethylene (TCE) and related chemicals.  ,  ;  . http://www.epa.gov/ncea/pdfs/tce/TCEMarch2001.pdf
• [39]Pesch B, Haerting J, Ranft U, Klimpel A, Oelschlagel B, Schill W: Occupational risk factors for renal cell carcinoma: agent-specific results from a case–control study in Germany, MURC Study Group. Multicenter urothelial and renal cancer study. Int J Epidemiol 2000, 29:1014-1024.
• [40]IARC: Dry cleaning, some chlorinated solvents and other industrial chemicals. IARC Monogr Eval Carcinog Risks Hum 1995, 63:33-477.
• [41]Brauch H, Weirich G, Hornauer MA, Störkel S, Wöhl T, Brüning T: Trichloroethylene exposure and specific somatic mutations in patients with renal cell carcinoma. J Natl Cancer Inst 1999, 91:854-861.
• [42]Brauch H, Weirich G, Klein B, Rabstein S, Bolt HM, Brüning T: VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference? Toxicol Lett 2004, 151:301-310.
• [43]Charbotel B, Gad S, Caïola D, Béroud C, Fevotte J, Bergeret A, Ferlicot S, Richard S: Trichloroethylene exposure and somatic mutations of the VHL gene in patients with Renal Cell Carcinoma. J Occup Med Toxicol 2007, 2:13. BioMed Central Full Text
• [44]Moore LE, Nickerson ML, Brennan P, Toro JR, Jaeger E, Rinsky J, Han SS, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Schmidt LS, Lenz P, Karami S, Linehan WM, Merino M, Chanock S, Boffetta P, Chow WH, Waldman FM, Rothman N: Von Hippel-Lindau (VHL) Inactivation in Sporadic Clear Cell Renal Cancer: Associations with Germline VHL Polymorphisms and Etiologic Risk Factors. PLoS Genet 2011, 7:e1002312.
• [45]Guo J, Kauppinen T, Kyyrönen P, Heikkila P, Lindbohm ML, Pukkala E: Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among Finnish workers exposed to diesel or gasoline engine exhaust. Int J Cancer 2004, 111:286-292.
• [46]Forastiere F, Perucci CA, Di Pietro A, Miceli M, Rpiti E, Bargagli A, Borgia P: Mortality among urban policemen in Rome. Am J Ind Med 1994, 26:785-798.
• [47]Delahunt B, Bethwaite PB, Nacey JN: Occupational risk for renal cell carcinoma. A case–control study based on the New Zealand Cancer Registry. Br J Urol 1995, 75:578-582.
• [48]Petralia SA, Dosemeci M, Adams EE, Zahm SH: Cancer mortality among women employed in health care occupations in 24 U.S. states, 1984–1993. Am J Ind Med 1999, 36:159-165.
• [49]DiGaetano R, Graubard B, Rao S, Severynse J, Wacholder S: Sampling racially matched population controls for case–control studies: using DMV lists and oversampling minorities. Federal Committee on Statistical Methodology Research Conference 2003, Concurrent Session IX-B. FCSM Statistical Policy Working Paper 37  . http://www.fcsm.gov/reports/