Hyperemesis gravidarum in the Medical Birth Registry of Norway – a validity study

BMC Pregnancy and Childbirth

Andrej M Grjibovski⁴  Sølvi Lomsdal¹  Siri Vangen²  Per Magnus⁵  Åse Vikanes³ 

[1] Department for Obstetrics and Gynecology, Innlandet Hospital, Lillehammer, Norway;National Resource Centre for Women’s Health, Department for Obstetrics and Gynecology, Oslo University Hospital Rikshospitalet, Oslo, Norway;Department of Obstetrics and Gynaecology and Medical Faculty Division, Akershus University Hospital, Lørenskog, Norway;International School of Public Health, Northern State Medical University, Arkhangelsk, Russia;Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway

关键词: Medical Birth Registry of Norway;    Validity study;    Hyperemesis gravidarum;   

Others  :  1152083
DOI  :  10.1186/1471-2393-12-115

 received in 2012-03-20, accepted in 2012-10-22,  发布年份 2012

【 摘 要 】

Background

Valid registration of medical information is essential for the quality of registry-based research. Hyperemesis gravidarum (HG) is characterized by severe nausea and vomiting, weight loss and electrolyte imbalance starting before 22nd gestational week. Given the fact that HG is a generally understudied disease which might have short- and long- term health consequences for mother and child, it is of importance to know whether potential misclassification bias influences the results of future studies. We therefore assessed the validity of the HG-registration in the in Medical Birth Registry of Norway (MBRN) using hospital records.

Methods

The sample comprised all women registered in MBRN with HG and who delivered at Ullevål and Akershus hospitals in 1.1.-31.3.1970, 1.4.-30.6.1986, 1.7.-30.9.1997 and 1.10.-31.12.2001. A random sample of 10 women per HG case, without HG according to MBRN, but who delivered during the same time periods at the same hospitals was also collected. The final sample included 551 women. Sensitivity, specificity, positive and negative predictive values (PPV and NPV) were estimated using strict and less strict diagnostic criteria of HG, indicating severe and mild HG, respectively. Hospital journals were used as gold standard.

Results

Using less strict diagnostic criteria of HG, sensitivity, specificity, PPV and NPV were 83.9% (95% CI: 67.4-92.9), 96.0% (95% CI: 93.9-97.3), 55.3% (95% CI: 41.2-68.6) and 99.0% (95% CI: 97.7-99.6), respectively. For strict diagnostic criteria, being hospitalised due to HG the corresponding values were 64% (95% CI: 38.8-87.2), 92% (95% CI: 90.2-94.6), 18.6% (95% CI: 10.2-31.9) and 99.0% (95% CI: 97.7-99.6).

Conclusions

The results from our study are comparable to previous research on disease registration in MBRN, and show that MBRN can be considered valid for mild HG but not for severe HG.

【 授权许可】

   
2012 Vikanes et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Franks ME, Macpherson GR, Figg WD: Thalidomide. Lancet 2004, 363:1802-1811.
• [2]Mcbride WG: Thalidomide and congenital abnormalities. Lancet 1961, 278:1358.
• [3]Irgens LM: The Medical Birth Registry of Norway. Epidemiological research and surveillance throughout 30 years. Acta Obstet Gynecol Scand 2000, 79:435-439.
• [4]Skomsvoll J, Ostensen M, Baste V, Irgens L: Validity of a rheumatic disease diagnosis in the Medical Birth Registry of Norway. Acta Obstet Gynecol Scand 2002, 81:831-834.
• [5]Engeland A, Bjorge T, Daltveit AK, Vollset SE, Furu K: Validation of disease registration in pregnant women in the Medical Birth Registry of Norway. Acta Obstet Gynecol Scand 2009, 88:1083-1089.
• [6]Hoff JM, Daltveit AK, Gilhus NE: Myasthenia gravis in pregnancy and birth: identifying risk factors, optimising care. Eur J Neurol 2007, 14:38-43.
• [7]Baghestan E, Bordahl PE, Rasmussen SA, Sande AK, Lyslo I, Solvang I: A validation of the diagnosis of obstetric sphincter tears in two Norwegian databases, the Medical Birth Registry and the Patient Administration System. Acta Obstet Gynecol Scand 2007, 86:205-209.
• [8]Rasmussen S, Albrechtsen S, Irgens LM, Dalaker K, Maartmann-Moe H, Vlatkovic L, et al.: Unexplained antepartum fetal death in Norway, 1985–97: diagnostic validation and some epidemiologic aspects. Acta Obstet Gynecol Scand 2003, 82:109-115.
• [9]Eliakim R, Abulafia O, Sherer DM: Hyperemesis gravidarum: a current review. Am J Perinatol 2000, 17:207-218.
• [10]Internation Classification of Diseases – ICD: Wolfbane Cybernetic Ltd. UK: Oxford; 2007. URL: http://www.wolfbane.com/icd/index.html webcite
• [11]Trogstad LI, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM: Recurrence risk in hyperemesis gravidarum. BJOG 2005, 112:1641-1645.
• [12]Basso O, Olsen J: Sex ratio and twinning in women with hyperemesis or pre-eclampsia. Epidemiology 2001, 12:747-749.
• [13]Vikanes ÅV, Grjibovski A, Vangen S, Magnus P: Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 births in Norway, 1967–2005. Scand J Public Health 2008, 36:135-142.
• [14]Verberg MF, Gillott DJ, Al Fardan N, Grudzinskas JG: Hyperemesis gravidarum, a literature review. Hum Reprod Update 2005, 11:527-539.
• [15]Bashiri A, Neumann L, Maymon E, Katz M: Hyperemesis gravidarum: epidemiologic features, complications and outcome. Eur J Obstet Gynecol Reprod Biol 1995, 63:135-138.
• [16]Depue RH, Bernstein L, Ross RK, Judd HL, Henderson BE: Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study. Am J Obstet Gynecol 1987, 156:1137-1141.
• [17]Källen B: Hyperemesis during pregnancy and delivery outcome: a registry study. Eur J Obstet Gynecol Reprod Biol 1987, 26:291-302.
• [18]Gadsby R, Barnie-Adshead AM, Jagger C: A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract 1993, 43:245-248.
• [19]Veenendaal MV, van Abeelen AF, Painter RC, van der Post JA, Roseboom TJ: Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG 2011, 118:1302-1313.
• [20]Jorgensen KT, Nielsen NM, Pedersen BV, Jacobsen S, Frisch M: Hyperemesis, gestational hypertensive disorders, pregnancy losses and risk of autoimmune diseases in a Danish population-based cohort. J Autoimmun 2012, 38:J120-J128.
• [21]Depue RH, Pike MC, Henderson BE: Estrogen exposure during gestation and risk of testicular cancer. J Natl Cancer Inst 1983, 71:1151-1155.
• [22]Roman E, Simpson J, Ansell P, Lightfoot T, Mitchell C, Eden TO: Perinatal and reproductive factors: a report on haematological malignancies from the UKCCS. Eur J Cancer 2005, 41:749-759.
• [23]Gerstman BB: Screening for Disease. Hoboken, New Jersey: Wiley-Liss,Inc; 2003:79-109. [Epidemiology Kept Simple]
• [24]Hære IM, Steinbakk A, Vikanes AV, Vilming B: Hyperemesis gravidarum-Veileder i Obstetrikk (Norwegian Guidelines for Obstetrics). Oslo, Norway: Legeforeningen; 2008. URL: http://legeforeningen.no/Fagmed/Norsk-gynekologisk-forening/Veiledere/veileder-i-fodselshjelp-2008/kapittel-7-hyperemesis-gravidarum/ webcite
• [25]Kristensen J, Langhoff-Roos J, Skovgaard LT, Kristensen FB: Validation of the danish birth registration. J Clin Epidemiol 1996, 49:893-897.
• [26]Cnattingius S, Ericson A, Gunnarskog J, Kallen B: A quality study of a medical birth registry. Scand J Soc Med 1990, 18:143-148.
• [27]Källen B, Lundberg G, Aberg A: Relationship between vitamin use, smoking, and nausea and vomiting of pregnancy. Acta Obstet Gynecol Scand 2003, 82:916-920.
• [28]Godsey RK, Newman RB: Hyperemesis gravidarum. A comparison of single and multiple admissions. J Reprod Med 1991, 36:287-290.
• [29]Dodds L, Fell DB, Joseph KS, Allen VM, Butler B: Outcomes of pregnancies complicated by hyperemesis gravidarum. Obstet Gynecol 2006, 107:285-292.
• [30]Gross S, Librach C, Cecutti A: Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome. Am J Obstet Gynecol 1989, 160:906-909.
• [31]Henderson BE, Benton B, Jing J, Yu MC, Pike MC: Risk factors for cancer of the testis in young men. Int J Cancer 1979, 23:598-602.
• [32]Mullin PM, Bray A, Schoenberg F, Macgibbon KW, Romero R, Goodwin TM, et al.: Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood. Journal of Developmental Origins of Health and Disease 2011, 2:200-204.