Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study

BMC Infectious Diseases

Khuanchai Supparatpinyo¹  Romanee Chaiwarith²  Rathakarn Kawila² 

[1] Research Institute for Health Sciences, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand;Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

关键词: Epidemiology;    HIV-uninfected individuals;    Penicilliosis marneffei;   

Others  :  1145709
DOI  :  10.1186/1471-2334-13-464

 received in 2013-06-06, accepted in 2013-09-20,  发布年份 2013

【 摘 要 】

Background

Penicilliosis marneffei is increasingly observed in individuals without HIV infection. This study aimed to compare the clinical and laboratory features among HIV infected and uninfected individuals with penicilliosis marneffei.

Methods

A retrospective cohort study was conducted between January 1, 2007 and December 31, 2011 at Chiang Mai University Hospital. We included individuals who were ≥15 years of age and presented with culture-proven P. marneffei infection.

Results

116 HIV-infected and 34 HIV-uninfected patients were enrolled. Comparing to HIV-infected patients, HIV-uninfected patients were older; less likely to have fever, splenomegaly, and umbilicated skin lesions; more likely to have Sweet’s syndrome and bone and joint infections; had higher white blood cell count, platelet count, and CD4 cell count; had lower alanine transaminase (ALT); and less likely to have positive fungal blood cultures. The mortality rates were 20.7% and 29.4% among HIV infected and uninfected patients, respectively.

Conclusions

Clinical manifestations of penicilliosis marneffei are different between patients with and without HIV infection. Physician’s awareness of this disease in HIV-uninfected patients may prompt the diagnosis and timely treatment, and can lead to a better outcome.

【 授权许可】

   
2013 Kawila et al.; licensee BioMed Central Ltd.

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