Clear cell sarcoma of the kidney distinguished from synovial sarcoma using genetic analysis: a case report

BMC Research Notes

Yutaro Hayashi¹  Kenjiro Kohri¹  Yoshinobu Moritoki¹  Hidenori Nishio¹  Hideyuki Kamisawa¹  Kentaro Mizuno¹  Masahito Hirose¹ 

[1] Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Aichi, Japan

关键词: Pediatric renal tumor;    Sarcoma;    Gene analysis;   

Others  :  1164299
DOI  :  10.1186/s13104-015-1100-5

 received in 2015-03-08, accepted in 2015-03-26,  发布年份 2015

【 摘 要 】

Background

The most common pediatric renal neoplasm is Wilms tumor, but clear cell sarcoma of the kidney or synovial sarcoma of the kidney are also sometimes encountered. Accurate pathological diagnosis is important, because adjuvant therapies including chemotherapy and radiotherapy differ according to the pathological type.

Case presentation

A 9-year-old boy presented with a headache, and ultrasonography, computed tomography, and magnetic resonance imaging revealed a heterogeneous enhancement of soft tissue originating from the upper pole of the left kidney, measuring approximately 11.0 × 10.0 × 8.0 cm. A left radical nephrectomy was performed using an intraperitoneal approach through an anterior subcostal incision. Pathological examination suggested clear cell sarcoma of the kidney or synovial sarcoma of the kidney based on morphological and immunohistological features. Using genetic analysis, a final diagnosis of spindle cell pattern clear cell sarcoma of the kidney was made based on the absence of the SYT-SSX fusion gene. After adjuvant chemo-radiotherapy was administered, no recurrence or metastasis has been identified as of 60 months postoperatively.

Conclusion

In this case, it was difficult to discriminate clear cell sarcoma of the kidney from synovial sarcoma of the kidney based on histopathological examination alone, and genetic analysis was required. Accurate pathological diagnosis of pediatric renal tumor is important for determining optimal treatment and preventing recurrence and metastasis.

【 授权许可】

   
2015 Hirose et al.; licensee BioMed Central.

【 图 表 】

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