The association between fine particulate matter exposure during pregnancy and preterm birth: a meta-analysis

BMC Pregnancy and Childbirth

Tao Liu¹  Bo Zhang²  Chi Eung Danforn Lim⁵  Rachel Wai Chung Ng³  Chunmei Zhao⁴  Xiping Luo⁴  Xiaoli Sun⁴ 

[1] Environment and Health, Guangdong Provincial Key Medical Discipline of Twelfth Five-Year Plan, Guangzhou 511430, China;Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China;Sydney South West Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia;Gynecology Department, Guangdong Women and Children Hospital, No. 521, Xingnan Road, Panyu District, Guangzhou 511442, China;Faculty of Science, University of Technology Sydney, Ultimo, Australia

关键词: Adverse pregnancy outcome;    Meta-analysis;    Preterm birth;    Fine particulate matter;   

Others  :  1233188
DOI  :  10.1186/s12884-015-0738-2

 received in 2015-03-15, accepted in 2015-11-10,  发布年份 2015

【 摘 要 】

Background

Although several previous studies have assessed the association of fine particulate matter (PM _2.5 ) exposure during pregnancy with preterm birth, the results have been inconsistent and remain controversial. This meta-analysis aims to quantitatively summarize the association between maternal PM _2.5exposure and preterm birth and to further explore the sources of heterogeneity in findings on this association.

Methods

We searched for all studies published before December 2014 on the association between PM _2.5exposure during pregnancy and preterm birth in the MEDLINE, PUBMED and Embase databases as well as the China Biological Medicine and Wanfang databases. A pooled OR for preterm birth in association with each 10 μg/m ³increase in PM _2.5exposure was calculated by a random-effects model (for studies with significant heterogeneity) or a fixed-effects model (for studies without significant heterogeneity).

Results

A total of 18 studies were included in this analysis. The pooled OR for PM _2.5exposure (per 10 μg/m ³increment) during the entire pregnancy on preterm birth was 1.13 (95 % CI = 1.03–1.24) in 13 studies with a significant heterogeneity (Q = 80.51, p < 0.001). The pooled ORs of PM _2.5exposure in the first, second and third trimester were 1.08 (95 % CI = 0.92–1.26), 1.09 (95 % CI = 0.82–1.44) and 1.08 (95 % CI = 0.99–1.17), respectively. The corresponding meta-estimates of PM _2.5effects in studies assessing PM _2.5exposure at individual, semi-individual and regional level were 1.11 (95 % CI = 0.89–1.37), 1.14 (95 % CI = 0.97–1.35) and 1.07 (95 % CI = 0.94–1.23). In addition, significant meta-estimates of PM _2.5exposures were found in retrospective studies (OR = 1.10, 95 % CI = 1.01–1.21), prospective studies (OR = 1.42, 95 % CI = 1.08–1.85), and studies conducted in the USA (OR = 1.16, 95 % CI = 1.05–1.29).

Conclusions

Maternal PM _2.5exposure during pregnancy may increase the risk of preterm birth,but significant heterogeneity was found between studies. Exposure assessment methods, study designs and study settings might be important sources of heterogeneity, and should be taken into account in future meta-analyses.

【 授权许可】

   
2015 Sun et al.

【 图 表 】

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