Effects of senktide, a neurokinin 3 receptor agonist, on luteinizing hormone secretion and follicular development in anestrous Shiba goats: a pilot study

BMC Research Notes

Tomomi Tanaka¹  Natsumi Endo¹ 

[1]Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-city, Tokyo 183-8509, Japan

关键词: Ovulation;    LH;    Senktide;    Goats;    Anestrus;   

Others  :  1125760
DOI  :  10.1186/1756-0500-7-773

 received in 2014-01-04, accepted in 2014-10-24,  发布年份 2014

【 摘 要 】

Background

Recent studies suggest that neurokinin B and its receptor, neurokinin 3 receptor, have an essential role in the regulation of gonadotropin-releasing hormone and luteinizing hormone (LH) release in several mammalian species. As the first trial, this pilot study reports the effect of intravenous treatment with senktide, a selective agonist of neurokinin 3 receptor, on LH secretion, follicular development in female goats that were clinically diagnosed with anestrus.

Findings

Anestrous goats were intravenously administered 200 nmol senktide at 4-h intervals for 24 h. Most of them examined (5/6 cases) showed a pulsatile increase in LH secretion after each injection of senktide, whereas the remaining one case showed a surge-like increase of LH secretion. Ovulation was confirmed in 5/6 cases at the range of 48–96 h after the beginning of treatment.

Conclusions

This pilot study demonstrated that intravenous treatment with senktide has therapeutic action in goats with anestrus by inducing LH release, which could promote follicular development and ovulation.

【 授权许可】

   
2014 Endo and Tanaka; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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