Is the difference in neonatal blood glucose concentration of caesarian and vaginally delivered term infants requiring separated reference intervals?

BMC Research Notes

Samuel Kinde³  Tilahun Teka³  Paulos Nigussie²  Mahilet Yigeremu³  Mulugeta Melkie¹ 

[1] Department of Medical Laboratory Science, Arbaminch University, Arbaminch, Ethiopia;Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia;Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

关键词: Robust method;    Cord blood glucose;    Cesarean section;    Vaginal delivery;    Neonatal hypoglycemia;    Reference interval;   

Others  :  1165630
DOI  :  10.1186/1756-0500-5-519

 received in 2012-06-19, accepted in 2012-09-21,  发布年份 2012

【 摘 要 】

Background

Mode of delivery has been reported to affect the cord blood glucose level of newborns. Vaginally delivered (VD) newborns were found to have relatively increased concentration of cord blood glucose than those delivered by cesarean section (CS). The aim of this study is thus to determine whether the difference in cord blood glucose concentration among VD and CS newborns is necessitating partitioned reference intervals (RIs) for the laboratory diagnosis of neonatal hypoglycemia.

Methods

A total of 60 newborns were included from Tikur Anbessa Specialized Hospital (TASH). Cord blood samples were collected and analyzed for glucose by Glucose-oxidase (GOD-PAP) method in TASH laboratory using HumaStar 300 from November 2010 to April 2011. All pre-analytical, analytical and post-analytical aspects were thoroughly controlled. A robust method was used for the determination of reference intervals using MedCalc® software Version 11.6.1.

Results

VD newborns accounted for 71.7% (n = 43) while the CS newborns accounted for 28.3% (n = 17). No statistically significant difference was noted in the studied demographic variables among VD and CS newborns except for blood glucose level. The RIs were then determined to be 2.46-6.85 mmol/l and 2.46-5.04 mmol/l for VD and CS newborns respectively. The combined RI was 2.24-6.48 mmol/l.

Conclusion

Combined RI better be used for the interpretation of cord blood glucose values in VD and CS newborns. Cord blood glucose concentrations of 2.24 mmol/l can be used as statistical estimates of cut off points for neonatal hypoglycemia in newborns irrespective of their mode of deliveries.

【 授权许可】

   
2012 Melkie et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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