Changes in serum cytokines in response to musculoskeletal surgical trauma

BMC Research Notes

Staale Petter Lyngstadaas¹  Janne Elin Reseland¹  Pål Borgen²  Olav Reikeras³ 

[1] Department of Biomaterials, Faculty of Dentistry, University of Oslo, Oslo, Norway;Martina Hansens Hospital, Gjettum, Norway;Department of Orthopaedics, Oslo University Clinic, Rikshospitalet, Oslo, Norway

关键词: Trauma;    Surgery;    Interleukins;    Inflammation;    Cytokines;   

Others  :  1134358
DOI  :  10.1186/1756-0500-7-128

 received in 2013-08-16, accepted in 2014-02-28,  发布年份 2014

【 摘 要 】

Background

Trauma induces local and subsequent systemic inflammatory reactions, and when the cytokine production is deregulated, a systemic inflammatory response syndrome with a potentially lethal outcome can occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions.

Methods

We analysed a panel of 30 cytokines in the serum of 20 patients operated with total hip replacement. Cytokine release was assessed postoperatively up to 6 days by a multiplex antibody bead kit and compared to pre-operative values.

Results

Surgery induced significant increments in serum levels of IL-2R at 6 days after surgery, in levels of IL-6 at 6 hours after surgery and at 1 day after surgery, in levels of IL-8 at 6 hours after surgery, in levels of IL-16 at 6 hours and at 1 day after surgery. Significant decreases in serum levels of IL-1Rα were found at the end of surgery, in levels of IL-12 at the end of surgery and at 6 hours after, and in levels of Eotaxin during all phases of the postoperative course.

Conclusions

The major findings were significant increases in systemic levels of the pro-inflammatory cytokines IL-6, IL-8, IL-16, while IL-12 was significantly decreased. Otherwise there were modest changes in the systemic cytokine kinetics and no significant expression of anti-inflammatory cytokines.

【 授权许可】

   
2014 Reikeras et al.; licensee BioMed Central Ltd.

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